Liver cancer is the second most frequent cause of cancer-related death globally. The main
histological subtype is hepatocellular carcinoma (HCC), which is derived from hepatocytes …

Abnormalities in the TP53 gene and overexpression of MDM2, a transcriptional target and
negative regulator of p53, are commonly observed in cancers. The MDM2–p53 feedback …

In chronic liver diseases (CLD), p53 is constitutively activated in hepatocytes due to various
etiologies as viral infection, ethanol exposure, or lipid accumulation. This study was aimed to …

The relationship between mdm2 gene expression and p53 gene mutation in hepatocellular
carcinoma (HCC) and their correlation with the invasiveness of the disease were …

Hepatoblastoma (HB) is the most common pediatric liver malignancy. High-risk patients
have poor survival, and current chemotherapies are associated with significant toxicities …

Background Misregulation of the p53-mdm2 loop function is a major mechanism to promote
hepatocellular carcinoma (HCC). RBM38, a member of the RNA recognition motif (RRM) …

The p53 tumor suppressor is a key transcription factor regulating cellular pathways such as
DNA repair, cell cycle, apoptosis, angiogenesis, and senescence. It acts as an important …

Tumor suppressor p53 plays a central role in preventing tumor formation. The levels and
activity of p53 is under tight regulation to ensure its proper function. Murine double minute 2 …

Abstract Background Tumor Protein p53 (p53), cyclin-dependent kinase inhibitor 1A
(p21/WAF1), and murine double minute 2 (MDM2) participate in the regulation of cell growth …

Poor prognosis of hepatocellular carcinoma (HCC) patients is frequently associated with
rapid tumor growth, recurrence and drug resistance. MT1G is a low-molecular weight protein …