Identification of Senescence-Related Biomarkers and Regulatory Networks in Intracerebral Hemorrhage

Y Wang, L Chen - The Neurologist, 2024 - journals.lww.com
Objectives: Intracerebral hemorrhage (ICH) is a severe neurological disorder with
substantial societal implications. Cellular senescence plays a critical role in ICH …

Preliminary Analysis of Aging-Related Genes in Intracerebral Hemorrhage by Integration of Bulk and Single-Cell RNA Sequencing Technology

Q Li, B Wang, J Yang, Y Wang, F Duan… - … Journal of General …, 2024 - Taylor & Francis
Background Aging is recognized as the key risk for intracerebral hemorrhage (ICH). The
detailed mechanisms of aging in ICH warrant exploration. This study aimed to identify …

Identification of potential biomarkers and small‑molecule compounds related to intracerebral hemorrhage with bioinformatics analysis

Z Yang, R Wang, X Chen, D Zhao - Acta Neurobiologiae Experimentalis, 2022 - ane.pl
This study aimed to further explore the underlying molecular mechanism of intracerebral
hemorrhage (ICH), gene expression profile GSE24265, containing perihematomal tissues …

[HTML][HTML] Identification of candidate blood mRNA biomarkers in intracerebral hemorrhage using integrated microarray and weighted gene co-expression network …

F Jin, L Li, Y Hao, L Tang, Y Wang, Z He - Frontiers in Genetics, 2021 - frontiersin.org
Purpose Intracerebral hemorrhage (ICH) is a serious public health hazard due to its high
morbidity, disability, and mortality. Currently, the exact molecular mechanisms of ICH are …

[HTML][HTML] Bioinformatics analysis of potential pathogenesis and risk genes of neuroinflammation-promoted brain injury in intracerebral hemorrhage

I Gareev, O Beylerli, E Musaev, C Wang, V Pavlov - Brain Hemorrhages, 2024 - Elsevier
Introduction Spontaneous (non-traumatic) intracerebral hemorrhage (ICH) is one of the
major causes of global death. The purpose of our bioinformatics analysis was to detect …

[HTML][HTML] Analysis of Age-Dependent Transcriptomic Changes in Response to Intracerebral Hemorrhage in Mice

X Li, W Yang, Y Shen, F Liu, X Xiong, Q Wu… - Frontiers in Molecular …, 2022 - frontiersin.org
Age is a well-known risk factor that is independently associated with poor outcomes after
intracerebral hemorrhage (ICH). However, the interrelationship between age and poor …

[HTML][HTML] Age-related changes after intracerebral hemorrhage: a comparative proteomics analysis of perihematomal tissue

X Li, Z Xiao, P Li, W Yang, Y Shen, F Liu… - … Biology and Medicine, 2024 - ncbi.nlm.nih.gov
The risk factors and causes of intracerebral hemorrhage (ICH) and the degree of functional
recovery after ICH are distinct between young and elderly patients. The increasing incidence …

Integrated multiomics analysis identifies a novel biomarker associated with prognosis in intracerebral hemorrhage

Y Shen, W Yang, X Xiong, X Li, Z Xiao… - Oxidative Medicine …, 2021 - Wiley Online Library
Existing treatments for intracerebral hemorrhage (ICH) are unable to satisfactorily prevent
development of secondary brain injury after ICH and multiple pathological mechanisms are …

[HTML][HTML] The use of multiple datasets to identify autophagy-related molecular mechanisms in intracerebral hemorrhage

Y Xiao, Y Zhang, C Wang, Y Ge, J Gao… - Frontiers in …, 2023 - frontiersin.org
Background: Intracerebral hemorrhage (ICH) is a stroke syndrome with high mortality and
disability rates, but autophagy's mechanism in ICH is still unclear. We identified key …

[HTML][HTML] A combined proteomics and bioinformatics approach reveals novel signaling pathways and molecular targets after intracerebral hemorrhage

R Dasari, W Zhi, F Bonsack… - Journal of Molecular …, 2020 - Springer
Intracerebral hemorrhage (ICH) is a non-traumatic cerebrovascular disorder with very high
morbidity and mortality and regarded as one of the deadliest stroke subtypes. Notably, there …