Enabling the paradigm of quality by design requires the ability to quantitatively correlate
material properties and process variables to measureable product performance attributes …

Background The pharmaceutical industry is continually striving to innovate drug
development and formulation processes. Orally disintegrating tablets (ODTs) have gained …

Oral disintegrating tablets (ODTs) are a novel dosage form that can be dissolved on the
tongue within 3 min or less especially for geriatric and pediatric patients. Current ODT …

One of the promising approaches to predict in vivo disintegration time of orally disintegrating
tablets (ODT) is the use of texture analyzer instrument. Once the method is able to provide …

Capping is the frequently observed mechanical defect in tablets arising from the sub-optimal
selection of the formulation composition and their robustness of response toward process …

An ultrasound measurement system was employed as a non-destructive method to evaluate
its reliability in predicting the tensile strength of tablets and investigate the benefits of …

Investigation of the effect of disintegrants on the disintegration time and hardness of rapidly
disintegrating tablets (RDTs) was carried out using a quality by design (QbD) paradigm …

Commonly used methods for analyzing tablet disintegration are based on visual
observations and can thus be user-dependent. To address this, a generally applicable …

The purpose of the study is to present the finite difference method (FDM) and demonstrate its
utility in modeling mass transport processes that are pharmaceutically relevant. In particular …

Capping is one of the mechanical defects in the tableting process in which catastrophic
failure of the compact can occur. Understanding what influences tablet capping in terms of …