HIV-1 uses the microtubule network to traffic the viral capsid core toward the nucleus. Viral
nuclear trafficking and infectivity require the kinesin-1 adaptor protein FEZ1. Here, we …

Although microtubule motors mediate intracellular virus transport, the underlying interactions
and control mechanisms remain poorly defined. This is particularly true for HIV-1 cores …

Intracellular transport of cargos, including many viruses, involves directed movement on
microtubules mediated by motor proteins. Although a number of viruses bind motors of …

The capsid (CA) protein of the human immunodeficiency virus type 1 (HIV-1) is an essential
structural component of a virion and facilitates many crucial life cycle steps through …

Microtubules (MTs) form a filamentous array that provide both structural support and a
coordinated system for the movement and organization of macromolecular cargos within the …

In infectious HIV-1 particles, the capsid protein (CA) forms a cone-shaped shell called the
capsid, which encases the viral ribonucleoprotein complex (vRNP). Following cellular entry …

Following envelope mediated fusion, the HIV-1 core is released into the cytoplasm of the
target cell and undergoes a series of trafficking and replicative steps that result in the …

The HIV-1 capsid is involved in all infectious steps from reverse transcription to integration
site selection, and is the target of multiple host cell and pharmacologic ligands. However …

The HIV-1 capsid is an ordered protein shell that houses the viral genome during early
infection. Its expansive surface consists of an ordered and interfacing array of capsid protein …

Cleavage and polyadenylation specificity factor 6 (CPSF6) is a human protein that binds HIV-
1 capsid and mediates nuclear transport and integration targeting of HIV-1 preintegration …