Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice

P Beckerman, J Bi-Karchin, ASD Park, C Qiu… - Nature medicine, 2017 - nature.com
African Americans have a heightened risk of developing chronic and end-stage kidney
disease, an association that is largely attributed to two common genetic variants, termed G1 …

APOL1–mediated cell injury involves disruption of conserved trafficking processes

E Kruzel-Davila, R Shemer, A Ofir… - Journal of the …, 2017 - journals.lww.com
APOL1 harbors C–terminal sequence variants (G1 and G2), which account for much of the
increased risk for kidney disease in sub–Saharan African ancestry populations. Expression …

APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R

K Okamoto, JW Rausch, H Wakashin, Y Fu… - Communications …, 2018 - nature.com
APOL1 risk alleles associate with chronic kidney disease in African Americans, but the
mechanisms remain to be fully understood. We show that APOL1 risk alleles activate protein …

APOL1-G1 in nephrocytes induces hypertrophy and accelerates cell death

Y Fu, J Zhu, A Richman, Y Zhang, X Xie… - Journal of the …, 2017 - journals.lww.com
People of African ancestry carrying certain APOL1 mutant alleles are at elevated risk of
developing renal diseases. However, the mechanisms underlying APOL1-associated renal …

Intracellular APOL1 risk variants cause cytotoxicity accompanied by energy depletion

D Granado, D Müller, V Krausel… - Journal of the …, 2017 - journals.lww.com
Population genetic approaches have uncovered a strong association between kidney
diseases and two sequence variants of the APOL1 gene, called APOL1 risk variant G1 and …

APOL1-G0 or APOL1-G2 transgenic models develop preeclampsia but not kidney disease

LA Bruggeman, Z Wu, L Luo… - Journal of the …, 2016 - journals.lww.com
APOL1 risk variants are associated with kidney disease in blacks, but the mechanisms of
renal injury associated with APOL1 risk variants are unknown. Because APOL1 is unique to …

APOL1 risk variants enhance podocyte necrosis through compromising lysosomal membrane permeability

X Lan, A Jhaveri, K Cheng, H Wen… - American Journal …, 2014 - journals.physiology.org
Development of higher rates of nondiabetic glomerulosclerosis (GS) in African Americans
has been attributed to two coding sequence variants (G1 and G2) in the APOL1 gene. To …

Kidney disease-associated APOL1 variants have dose-dependent, dominant toxic gain-of-function

S Datta, R Kataria, JY Zhang, S Moore… - Journal of the …, 2020 - journals.lww.com
Background Two coding renal risk variants (RRVs) of the APOL1 gene (G1 and G2) are
associated with large increases in CKD rates among populations of recent African descent …

Genetic inhibition of APOL1 pore-forming function prevents APOL1-mediated kidney disease

AM Hung, VA Assimon, HC Chen, Z Yu… - Journal of the …, 2023 - journals.lww.com
Background African Americans are at increased risk for nondiabetic CKD in part due to HR
variants in the APOL1 gene. Methods We tested whether a different APOL1 variant, p …

APOL1 kidney disease risk variants: an evolving landscape

PD Dummer, S Limou, AZ Rosenberg, J Heymann… - Seminars in …, 2015 - Elsevier
Summary Apolipoprotein L1 (APOL1) genetic variants account for much of the excess risk of
chronic and end-stage kidney disease, which results in a significant global health disparity …