Contrasting benefits of different artemisinin combination therapies as first-line malaria treatments using model-based cost-effectiveness analysis
LC Okell, M Cairns, JT Griffin, NM Ferguson… - Nature …, 2014 - nature.com
There are currently several recommended drug regimens for uncomplicated falciparum
malaria in Africa. Each has different properties that determine its impact on disease burden …
malaria in Africa. Each has different properties that determine its impact on disease burden …
Modelling the impact of artemisinin combination therapy and long-acting treatments on malaria transmission intensity
Background Artemisinin derivatives used in recently introduced combination therapies
(ACTs) for Plasmodium falciparum malaria significantly lower patient infectiousness and …
(ACTs) for Plasmodium falciparum malaria significantly lower patient infectiousness and …
Artemisinin resistance–modelling the potential human and economic costs
Background Artemisinin combination therapy is recommended as first-line treatment for
falciparum malaria across the endemic world and is increasingly relied upon for treating …
falciparum malaria across the endemic world and is increasingly relied upon for treating …
Optimum population-level use of artemisinin combination therapies: a modelling study
TD Nguyen, P Olliaro, AM Dondorp, JK Baird… - The Lancet Global …, 2015 - thelancet.com
Summary Background Artemisinin combination therapies (ACTs) are used worldwide as first-
line treatment against confirmed or suspected Plasmodium falciparum malaria. Despite the …
line treatment against confirmed or suspected Plasmodium falciparum malaria. Despite the …
[HTML][HTML] A threshold analysis of the cost-effectiveness of artemisinin-based combination therapies in sub-saharan Africa
PG Coleman, C Morel, SAM Shillcutt… - … Intolerable Burden of …, 2004 - ncbi.nlm.nih.gov
Artemisinin-based combination therapies (ACTs) are generally regarded as vital in
addressing the growing problem posed by the development of antimalarial resistance …
addressing the growing problem posed by the development of antimalarial resistance …
Optimizing the programmatic deployment of the anti-malarials artemether-lumefantrine and dihydroartemisinin-piperaquine using pharmacological modelling
Background Successful programmatic use of anti-malarials faces challenges that are not
covered by standard drug development processes. The development of appropriate …
covered by standard drug development processes. The development of appropriate …
Global estimation of anti-malarial drug effectiveness for the treatment of uncomplicated Plasmodium falciparum malaria 1991–2019
G Rathmes, SF Rumisha, TCD Lucas, KA Twohig… - Malaria journal, 2020 - Springer
Background Anti-malarial drugs play a critical role in reducing malaria morbidity and
mortality, but their role is mediated by their effectiveness. Effectiveness is defined as the …
mortality, but their role is mediated by their effectiveness. Effectiveness is defined as the …
Investigating the efficacy of triple artemisinin-based combination therapies for treating Plasmodium falciparum malaria patients using mathematical modeling
The first line treatment for uncomplicated falciparum malaria is artemisinin-based
combination therapy (ACT), which consists of an artemisinin derivative coadministered with …
combination therapy (ACT), which consists of an artemisinin derivative coadministered with …
The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data
… Antimalarial Resistance Network (WWARN) AS-AQ … - BMC medicine, 2015 - Springer
Abstract Background Artesunate-amodiaquine (AS-AQ) is one of the most widely used
artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium …
artemisinin-based combination therapies (ACTs) to treat uncomplicated Plasmodium …
Antimalarial drug resistance, artemisinin-based combination therapy, and the contribution of modeling to elucidating policy choices.
S Yeung, W Pongtavornpinyo… - … journal of tropical …, 2004 - researchonline.lshtm.ac.uk
Increasing resistance of Plasmodium falciparum malaria to antimalarial drugs is posing a
major threat to the global effort to" Roll Back Malaria". Chloroquine and sulfadoxine …
major threat to the global effort to" Roll Back Malaria". Chloroquine and sulfadoxine …