Nicotinamide adenine dinucleotide (NAD+) extends longevity in experimental organisms,
raising interest in its impact on human health. De novo NAD+ biosynthesis from tryptophan …

The biosynthetic routes leading to de novo nicotinamide adenine dinucleotide (NAD+)
production are involved in acute kidney injury (AKI), with a critical role for quinolinate …

The energetic burden of continuously concentrating solutes against gradients along the
tubule may render the kidney especially vulnerable to ischaemia. Acute kidney injury (AKI) …

The mammalian kidney relies on abundant mitochondria in the renal tubule to generate
sufficient ATP to provide the energy required for constant reclamation of solutes from crude …

Objective A decay in intracellular NAD+ levels is one of the hallmarks of physiological
decline in normal tissue functions. Accordingly, dietary supplementation with NAD+ …

The conceptual evolution of nicotinamide adenine dinucleotide (NAD+) from being seen as
a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and …

The role in longevity and healthspan of nicotinamide (NAM), the physiological precursor of
NAD+, is elusive. Here, we report that chronic NAM supplementation improves healthspan …

Nicotinamide riboside (NR) is in wide use as an NAD+ precursor vitamin. Here we
determine the time and dose-dependent effects of NR on blood NAD+ metabolism in …

Nicotinamide adenine dinucleotide (NAD+) biosynthesis and its regulation have recently
been attracting markedly increasing interest. Aging is marked by a systemic decrease in …

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in all living cells. It serves
both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying …