Since the first description of their opioid properties three decades ago, dynorphins have
increasingly been thought to play a regulatory role in numerous functional pathways of the …

This issue of Molecular Pharmacology is dedicated to Dr. Avram Goldstein, the journal's
founding editor and one of the leaders in the development of modern pharmacology. This …

The opioid system has important roles in controlling pain, reward and addiction, and is
implicated in numerous other processes within and outside the nervous system, such as …

Dynorphins, endogenous opioid neuropeptides derived from the prodynorphin gene, are
involved in a variety of normative physiologic functions including antinociception and …

Neuropsychiatric disorders are one of the main challenges of human medicine with epilepsy
being one of the most common serious disorders of the brain. Increasing evidence suggest …

The dynorphin/kappa opioid receptor (KOR) system has been implicated in many aspects
that influence neuropsychiatric disorders. Namely, this system modulates neural circuits that …

The dynorphin/κ-opioid receptor system has been implicated in the pathogenesis and
pathophysiology of several psychiatric disorders. In the present review, we present evidence …

Studies on dynorphin involvement in epilepsy are summarised in this review.
Electrophysiological, biochemical and pharmacological data support the hypothesis that …

The dynorphin-like peptides have profound effects on the state of the brain reward system
and human and animal behavior. The dynorphin-like peptides affect locomotor activity, food …

Dynorphin A is an endogenous opioid peptide that preferentially activates κ-opioid receptors
and is antinociceptive at physiological concentrations. Levels of dynorphin A and a major …