NLRP3 inflammasome can be widely found in epithelial cells and immune cells. The NOD-
like receptors (NLRs) family member NLRP3 contains a central nucleotide-binding and …

Several lines of evidence point out the relevance of nucleotide-binding oligomerization
domain leucine rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome …

Inflammasomes are multiprotein intracellular complexes which are responsible for the
activation of inflammatory responses. Among various subtypes of inflammasomes, NLRP3 …

Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis constitute
a major health problem in developed countries. Moreover, IBD predisposes to the …

Decreased expression of the Nlrp3 protein is associated with susceptibility to Crohn's
disease. However, the role of Nlrp3 in colitis has not been characterized. Nlrp3 interacts with …

The NOD‐like receptor family pyrin domain containing 6 (NLRP6), a member of the NOD‐
like receptor (NLR) family, acts as a cytosolic innate immune sensor that recognizes microbe …

Background and Aims: NLRP3 inflammasome is known to be involved in inflammatory
bowel diseases. However, it is controversial whether it is pathogenic or beneficial. This study …

Background Attenuated innate immune responses to the intestinal microbiota have been
linked to the pathogenesis of Crohn's disease (CD). Recent genetic studies have revealed …

Cases of inflammatory bowel disease (IBD), a debilitating intestinal disorder with complex
pathological mechanisms, have been increasing in recent years, straining the capacity of …

Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and
small intestine, comprised of ulcerative colitis and Crohn's disease. Among the complicated …