Immunometabolic pathways in BCG-induced trained immunity

RJW Arts, A Carvalho, C La Rocca, C Palma… - Cell reports, 2016 - cell.com
The protective effects of the tuberculosis vaccine Bacillus Calmette-Guerin (BCG) on
unrelated infections are thought to be mediated by long-term metabolic changes and …

BCG-induced cross-protection and development of trained immunity: implication for vaccine design

C Covián, A Fernández-Fierro, A Retamal-Díaz… - Frontiers in …, 2019 - frontiersin.org
The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the
ability to induce non-specific cross-protection against pathogens that might be unrelated to …

Stronger induction of trained immunity by mucosal BCG or MTBVAC vaccination compared to standard intradermal vaccination

MPM Vierboom, K Dijkman, CC Sombroek… - Cell Reports …, 2021 - cell.com
BCG vaccination can strengthen protection against pathogens through the induction of
epigenetic and metabolic reprogramming of innate immune cells, a process called trained …

[HTML][HTML] Single-cell transcriptomic profiles reveal changes associated with BCG-induced trained immunity and protective effects in circulating monocytes

L Kong, SJ Moorlag, A Lefkovith, B Li, V Matzaraki… - Cell reports, 2021 - cell.com
Summary Bacillus Calmette-Guérin (BCG) vaccine is one of the most widely used vaccines
worldwide. In addition to protection against tuberculosis, BCG confers a degree of non …

BCG vaccination induces cross-protective immunity against pathogenic microorganisms

JA Soto, NMS Gálvez, CA Andrade, MA Ramírez… - Trends in …, 2022 - cell.com
Bacillus Calmette-Guérin (BCG) is an attenuated Mycobacterium bovis strain used as a
vaccine to prevent Mycobacterium tuberculosis (M. tb) infection. Its ability to potentiate the …

[HTML][HTML] BCG vaccination induces long-term functional reprogramming of human neutrophils

SJ Moorlag, YA Rodriguez-Rosales, J Gillard… - Cell reports, 2020 - cell.com
The tuberculosis vaccine bacillus Calmette-Guérin (BCG) protects against some
heterologous infections, probably via induction of non-specific innate immune memory in …

Anti-mycobacterial activity correlates with altered DNA methylation pattern in immune cells from BCG-vaccinated subjects

D Verma, VR Parasa, J Raffetseder, M Martis… - Scientific reports, 2017 - nature.com
The reason for the largely variable protective effect against TB of the vaccine Bacille
Calmette-Guerin (BCG) is not understood. In this study, we investigated whether epigenetic …

BCG-induced trained immunity: history, mechanisms and potential applications

J Chen, L Gao, X Wu, Y Fan, M Liu, L Peng… - Journal of Translational …, 2023 - Springer
Abstract The Bacillus Calmette-Guérin (BCG) vaccine was discovered a century ago and
has since been clinically applicable. BCG can not only be used for the prevention of …

Characterizing the BCG Induced Macrophage and Neutrophil Mechanisms for Defense Against Mycobacterium tuberculosis

TE Bickett, J McLean, E Creissen, L Izzo… - Frontiers in …, 2020 - frontiersin.org
The live attenuated Mycobacterium bovis strain, Bacille Calmette Guérin (BCG) is a potent
innate immune stimulator. In the C57BL/6 mouse model of tuberculosis, BCG vaccination …

BCG turns 100: its nontraditional uses against viruses, cancer, and immunologic diseases

AK Singh, MG Netea, WR Bishai - The Journal of clinical …, 2021 - Am Soc Clin Investig
First administered to a human subject as a tuberculosis (TB) vaccine on July 18, 1921,
Bacillus Calmette-Guérin (BCG) has a long history of use for the prevention of TB and later …