Omicron: a heavily mutated SARS-CoV-2 variant exhibits stronger binding to ACE2 and potently escapes approved COVID-19 therapeutic antibodies

M Shah, HG Woo - Frontiers in immunology, 2022 - frontiersin.org
The new SARS-CoV-2 variant of concern “Omicron” was recently spotted in South Africa and
spread quickly around the world due to its enhanced transmissibility. The variant became …

An ACE2-blocking antibody confers broad neutralization and protection against Omicron and other SARS-CoV-2 variants of concern

W Du, DL Hurdiss, D Drabek, AZ Mykytyn… - Science …, 2022 - science.org
The ongoing evolution of SARS-CoV-2 has resulted in the emergence of Omicron, which
displays notable immune escape potential through mutations at key antigenic sites on the …

Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry

J Ge, R Wang, B Ju, Q Zhang, J Sun, P Chen… - Nature …, 2021 - nature.com
Understanding the mechanism for antibody neutralization of SARS-CoV-2 is critical for the
development of effective therapeutics and vaccines. We recently isolated a large number of …

Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation

NK Hurlburt, E Seydoux, YH Wan, VV Edara… - Nature …, 2020 - nature.com
SARS-CoV-2 is a betacoronavirus virus responsible for the COVID-19 pandemic. Here, we
determine the X-ray crystal structure of a potent neutralizing monoclonal antibody, CV30 …

Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species

R Wang, Q Zhang, J Ge, W Ren, R Zhang, J Lan, B Ju… - Immunity, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants continue to
emerge during the global pandemic and may facilitate escape from current antibody …

SARS-CoV-2 Omicron RBD shows weaker binding affinity than the currently dominant Delta variant to human ACE2

L Wu, L Zhou, M Mo, T Liu, C Wu, C Gong… - Signal transduction and …, 2022 - nature.com
SARS-coronavirus-2 (SARS-CoV-2) Omicron variant (B. 1.1. 529) is of great concern to the
world due to its multiple mutations that may have an impact on transmissibility and immune …

Omicron: Master of immune evasion maintains robust ACE2 binding

M Hoffmann, L Zhang, S Pöhlmann - Signal Transduction and Targeted …, 2022 - nature.com
The spike (S) protein of the SARS-CoV-2 Omicron variant is highly mutated but the impact of
these mutations on viral entry into cells and its inhibition by antibodies has been unclear. A …

A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants

Z Yang, Y Wang, Y Jin, Y Zhu, Y Wu, C Li… - Signal transduction and …, 2021 - nature.com
The current COVID-19 pandemic has heavily burdened the global public health system and
may keep simmering for years. The frequent emergence of immune escape variants have …

Resilience of S309 and AZD7442 monoclonal antibody treatments against infection by SARS-CoV-2 Omicron lineage strains

JB Case, S Mackin, JM Errico, Z Chong… - Nature …, 2022 - nature.com
Omicron variant strains encode large numbers of changes in the spike protein compared to
historical SARS-CoV-2 isolates. Although in vitro studies have suggested that several …

Increased immune escape of the new SARS-CoV-2 variant of concern Omicron

J Hu, P Peng, X Cao, K Wu, J Chen, K Wang… - Cellular & Molecular …, 2022 - nature.com
On 24 November, a new detected variant B. 1.1. 529 of SARS-CoV-2 by South Africa was
reported to WHO. After only 2 days, this variant was designated as “variant of concern”(VOC) …