Extrasynaptic actions of glutamate are limited by high-affinity transporters expressed by
perisynaptic astroglial processes (PAPs): this helps maintain point-to-point transmission in …

Presynaptic glutamate replenishment is fundamental to brain function. In high activity
regimes, such as epileptic episodes, this process is thought to rely on the glutamate …

The late-phase of long-term potentiation (L-LTP), the cellular correlate of long-term memory,
induced at some synapses facilitates L-LTP expression at other synapses receiving …

Long-term potentiation (LTP) of synaptic transmission represents the cellular basis of
learning and memory. Astrocytes have been shown to regulate synaptic transmission and …

Long-term potentiation (LTP) of synaptic transmission is thought to be an important cellular
mechanism underlying memory formation. A widely accepted model posits that LTP requires …

Most excitatory glutamatergic synapses contain both AMPA and NMDA receptors, but
whether these receptors are regulated together or independently during synaptic plasticity …

Astrocytes have long been regarded as essentially unexcitable cells that do not contribute to
active signaling and information processing in the brain. Contrary to this classical view, it is …

Chronic inactivation of a neural network is known to induce homeostatic upregulation of
synaptic strength, a form of synaptic plasticity that differs from Hebbian-type synaptic …

In the mammalian brain most excitatory transmission is mediated by glutamate binding to
AMPA and NMDA receptors. These receptors have markedly different biophysical …

The spatiotemporal dynamics of excitatory neurotransmission must be tightly regulated to
achieve efficient synaptic communication. By limiting spillover, glutamate transporters are …