Transcription factor (TF) proteins bind to DNA to regulate gene expression. Normally,
accessibility to DNA is required for their function. However, in the nucleus, the DNA is often …

Pioneer transcription factors are proteins that induce cellular identity transitions by binding to
inaccessible regions of DNA in nuclear chromatin. They contribute to chromatin opening and …

Critical lineage commitment events are staged by multiple transcription factors (TFs) binding
to their cognate motifs, often positioned at nucleosome-enriched regions of chromatin. The …

Transcription factor binding to genomic DNA is generally prevented by nucleosome
formation, in which the DNA is tightly wrapped around the histone octamer. In contrast …

Pioneer transcription factors such as OCT4 can target silent genes embedded in
nucleosome-dense regions. How nucleosome interaction enables transcription factors to …

While recent experiments revealed that some pioneer transcription factors (TFs) can bind to
their target DNA sequences inside a nucleosome, the binding dynamics of their target …

Transcription factors (TFs) regulate gene expression through chromatin where nucleosomes
restrict DNA access. To study how TFs bind nucleosome-occupied motifs, we focused on the …

Pioneer transcription factors (pTFs) can bind directly to silent chromatin and promote vital
transcriptional programs. Here, by integrating high-resolution nuclear magnetic resonance …

Pioneer transcription factors are essential for cell fate changes by targeting closed
chromatin. OCT4 is a crucial pioneer factor that can induce cell reprogramming. However …

Cooperative binding of transcription factors (TFs) to chromatin orchestrates gene expression
programming and cell fate specification. However, the biophysical principles of TF …