MicroRNAs are post-transcriptional regulators of gene expression, crucial for neuronal
differentiation, survival, and activity. Age-related dysregulation of microRNA biogenesis …

While the root causes for individual neurodegenerative diseases are distinct, many shared
pathological features and mechanisms contribute to neurodegeneration across diseases …

The complexity of the nervous system arises in part, from the large diversity of neural cell
types that support the architecture of neuronal circuits. Recent studies have highlighted …

The last decade has experienced the emergence of microRNAs as a key molecular tool for
the diagnosis and prognosis of human diseases. Although the focus has mostly been on …

Neurodegenerative diseases are debilitating and currently incurable conditions causing
severe cognitive and motor impairments, defined by the progressive deterioration of …

The central nervous system can respond to threat via the induction of an inflammatory
response. Under normal circumstances this response is tightly controlled, however …

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
Huntington's disease (HD) and amyotrophic lateral sclerosis (ALS), originate from a loss of …

Oxidative stress (OS) is one of the major pathomechanisms of Alzheimer's disease (AD),
which is closely associated with other key events in neurodegeneration such as …

Neurodegenerative diseases are typically late-onset, progressive disorders that affect neural
function and integrity. Although most attention has been focused on the genetic …

Neurodegeneration is characterized by the progressive loss of neuronal cell types in the
nervous system. Although the main cause of cell dysfunction and death in many …