miRNA–target chimeras reveal miRNA 3′-end pairing as a major determinant of Argonaute target specificity
Abstract microRNAs (miRNAs) act as sequence-specific guides for Argonaute (AGO)
proteins, which mediate posttranscriptional silencing of target messenger RNAs. Despite …
proteins, which mediate posttranscriptional silencing of target messenger RNAs. Despite …
[HTML][HTML] Argonaute divides its RNA guide into domains with distinct functions and RNA-binding properties
MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) guide Argonaute proteins to
silence mRNA expression. Argonaute binding alters the properties of an RNA guide …
silence mRNA expression. Argonaute binding alters the properties of an RNA guide …
A dynamic search process underlies microRNA targeting
SD Chandradoss, NT Schirle, M Szczepaniak… - Cell, 2015 - cell.com
Argonaute proteins play a central role in mediating post-transcriptional gene regulation by
microRNAs (miRNAs). Argonautes use the nucleotide sequences in miRNAs as guides for …
microRNAs (miRNAs). Argonautes use the nucleotide sequences in miRNAs as guides for …
Genome-wide identification of miRNA targets by PAR-CLIP
miRNAs are short (20–23nt) RNAs that are loaded into proteins of the Argonaute (AGO)
family and guide them to partially complementary target sites on mRNAs, resulting in mRNA …
family and guide them to partially complementary target sites on mRNAs, resulting in mRNA …
miRNA targeting: growing beyond the seed
LB Chipman, AE Pasquinelli - Trends in genetics, 2019 - cell.com
miRNAs are small RNAs that guide Argonaute proteins to specific target mRNAs to repress
their translation and stability. Canonically, miRNA targeting is reliant on base pairing of the …
their translation and stability. Canonically, miRNA targeting is reliant on base pairing of the …
Beyond the seed: structural basis for supplementary micro RNA targeting by human Argonaute2
Abstract micro RNA s (mi RNA s) guide Argonaute proteins to mRNA s targeted for
repression. Target recognition occurs primarily through the mi RNA seed region, composed …
repression. Target recognition occurs primarily through the mi RNA seed region, composed …
High-throughput analysis reveals rules for target RNA binding and cleavage by AGO2
Argonaute proteins loaded with microRNAs (miRNAs) or small interfering RNAs (siRNAs)
form the RNA-induced silencing complex (RISC), which represses target RNA expression …
form the RNA-induced silencing complex (RISC), which represses target RNA expression …
Helix‐7 in Argonaute2 shapes the microRNA seed region for rapid target recognition
SM Klum, SD Chandradoss, NT Schirle, C Joo… - The EMBO …, 2018 - embopress.org
Argonaute proteins use micro RNA s (mi RNA s) to identify mRNA s targeted for post‐
transcriptional repression. Biochemical assays have demonstrated that Argonaute functions …
transcriptional repression. Biochemical assays have demonstrated that Argonaute functions …
The biochemical basis of microRNA targeting efficacy
INTRODUCTION MicroRNAs (miRNAs) are short RNAs that guide repression of mRNA
targets. Each miRNA associates with an Argonaute (AGO) protein to form a complex in …
targets. Each miRNA associates with an Argonaute (AGO) protein to form a complex in …
Structural determinants of miRNAs for RISC loading and slicer-independent unwinding
T Kawamata, H Seitz, Y Tomari - Nature structural & molecular biology, 2009 - nature.com
MicroRNAs (miRNAs) regulate expression of their target mRNAs through the RNA-induced
silencing complex (RISC), which contains an Argonaute (Ago) family protein as a core …
silencing complex (RISC), which contains an Argonaute (Ago) family protein as a core …