[HTML][HTML] Big science and big data in nephrology

J Saez-Rodriguez, MM Rinschen, J Floege… - Kidney international, 2019 - Elsevier
There have been tremendous advances during the last decade in methods for large-scale,
high-throughput data generation and in novel computational approaches to analyze these …

Big data in nephrology

N Kaur, S Bhattacharya, AJ Butte - Nature Reviews Nephrology, 2021 - nature.com
A huge array of data in nephrology is collected through patient registries, large
epidemiological studies, electronic health records, administrative claims, clinical trial …

Big data in nephrology: Are we ready for the change?

C Yang, G Kong, L Wang, L Zhang, MH Zhao - Nephrology, 2019 - Wiley Online Library
Chronic kidney disease (CKD) is a major public health issue worldwide. However, the status
of kidney health care needs to be strengthened globally and research evidence in …

[HTML][HTML] Promises of big data and artificial intelligence in nephrology and transplantation

C Thongprayoon, W Kaewput, K Kovvuru… - Journal of clinical …, 2020 - mdpi.com
Kidney diseases form part of the major health burdens experienced all over the world.
Kidney diseases are linked to high economic burden, deaths, and morbidity rates. The great …

Rationale and design of the kidney precision medicine project

IH de Boer, CE Alpers, EU Azeloglu, UGJ Balis… - Kidney international, 2021 - Elsevier
Chronic kidney disease (CKD) and acute kidney injury (AKI) are common, heterogeneous,
and morbid diseases. Mechanistic characterization of CKD and AKI in patients may facilitate …

From-omics to personalized medicine in nephrology: integration is the key

F Pesce, S Pathan, FP Schena - Nephrology Dialysis …, 2013 - academic.oup.com
Large-scale gene, protein and metabolite measurements ('omics') have driven the resolution
of biology to an unprecedented high definition. Passing from reductionism to a system …

[HTML][HTML] Medical big data: promise and challenges

CH Lee, HJ Yoon - Kidney research and clinical practice, 2017 - ncbi.nlm.nih.gov
The concept of big data, commonly characterized by volume, variety, velocity, and veracity,
goes far beyond the data type and includes the aspects of data analysis, such as hypothesis …

Next-generation sequencing for research and diagnostics in kidney disease

KY Renkema, MF Stokman, RH Giles… - Nature Reviews …, 2014 - nature.com
The advent of next-generation sequencing technologies has enabled genetic nephrology
research to move beyond single gene analysis to the simultaneous investigation of …

[HTML][HTML] From big data to precision medicine

T Hulsen, SS Jamuar, AR Moody, JH Karnes… - Frontiers in …, 2019 - frontiersin.org
For over a decade the term “Big data” has been used to describe the rapid increase in
volume, variety and velocity of information available, not just in medical research but in …

[HTML][HTML] Systems biology and kidney disease

JA Schaub, H Hamidi, L Subramanian… - Clinical Journal of the …, 2020 - journals.lww.com
The kidney is a complex organ responsible for maintaining multiple aspects of homeostasis
in the human body. The combination of distinct, yet interrelated, molecular functions across …