M Coradazzi, R Gulino, F Fieramosca… - Neurobiology of …, 2016 - Elsevier
Noradrenergic neurons in the locus coeruleus play a role in learning and memory, and their loss is an early event in Alzheimer's disease pathogenesis. Moreover, noradrenaline may …
A growing body of evidence demonstrates the important role of the noradrenergic system in the pathogenesis of many neurodegenerative processes, especially Alzheimer's disease …
C Slater, Q Wang - Clinical and Translational Medicine, 2021 - Wiley Online Library
Alzheimer's disease (AD) poses a significant global health concern over the next several decades. Multiple hypotheses have been put forth that attempt to explain the underlying …
S Kalinin, V Gavrilyuk, PE Polak, R Vasser, J Zhao… - Neurobiology of …, 2007 - Elsevier
Loss of Locus coeruleus (LC) noradrenergic (NA) neurons occurs in several neurodegenerative conditions including Alzheimer's disease (AD). In vitro and in vivo …
RWE van Hooren, FRJ Verhey, IHGB Ramakers… - Neurobiology of …, 2021 - Elsevier
Advanced Alzheimer's disease (AD) is characterized by higher noradrenaline metabolite levels that may be associated with AD pathology. The locus coeruleus (LC) is the main site …
IH Robertson - Neurobiology of aging, 2013 - Elsevier
The gap between symptoms and pathology in Alzheimer's disease has been explained by the hypothetical construct of “cognitive reserve”—a set of variables including education …
G Leanza, R Gulino, R Zorec - Frontiers in Molecular Neuroscience, 2018 - frontiersin.org
In the past, manipulation of the cholinergic system was seen as the most likely therapeutic for neurodegeneration-based cognitive decline in Alzheimer's disease (AD)(Whitehouse et …
MR Marien, FC Colpaert, AC Rosenquist - Brain Research Reviews, 2004 - Elsevier
A deficiency in the noradrenergic system of the brain, originating largely from cells in the locus coeruleus (LC), is theorized to play a critical role in the progression of a family of …
SE Counts, EJ Mufson - Journal of neurochemistry, 2010 - Wiley Online Library
J. Neurochem.(2010) 113, 649–660. Abstract Degeneration of locus coeruleus (LC) noradrenergic forebrain projection neurons is an early feature of Alzheimer's disease. The …