Comparison of the immunogenicity and protective efficacy of ACAM2000, MVA, and vectored subunit vaccines for Mpox in rhesus macaques

C Jacob-Dolan, D Ty, D Hope, K McMahan… - Science Translational …, 2024 - science.org
The 2022–2023 mpox outbreak triggered vaccination efforts using smallpox vaccines that
were approved for mpox, including modified vaccinia Ankara (MVA; JYNNEOS), which is a …

Mpox neutralizing antibody response to LC16m8 vaccine in healthy adults

E Morino, S Mine, N Tomita, Y Uemura… - NEJM …, 2024 - evidence.nejm.org
Background Vaccination against mpox (formerly known as monkeypox), an infectious
disease caused by the monkeypox virus (MPXV), is needed to prevent outbreaks and …

[HTML][HTML] Monkeypox breakthrough infections and side-effects: Clarion call for nex-gen novel vaccine

RK Mohapatra, S Mishra, AA Rabaan… - New Microbes and …, 2023 - ncbi.nlm.nih.gov
Monkeypox (mpox) virus belongs to the same family as variola virus causing smallpox.
Usually spreading through skin-to-skin contact with the mpox-infected and causing rashes …

Mpox multi-antigen mRNA vaccine candidates by a simplified manufacturing strategy afford efficient protection against lethal orthopoxvirus challenge

J Zeng, Y Li, L Jiang, L Luo, Y Wang… - Emerging microbes & …, 2023 - Taylor & Francis
Current unprecedented mpox outbreaks in non-endemic regions represent a global public
health concern. Although two live-attenuated vaccinia virus (VACV)-based vaccines have …

[HTML][HTML] Real-world effectiveness of a single dose of mpox vaccine in males

Y Wolff Sagy, R Zucker, A Hammerman, H Markovits… - Nature Medicine, 2023 - nature.com
The recent global outbreak of the monkeypox (mpox) virus in humans was declared a public
health emergency by the World Health Organization in July 2022. The smallpox and mpox …

[HTML][HTML] Synthetic modified vaccinia Ankara vaccines confer cross-reactive and protective immunity against mpox virus

F Chiuppesi, JA Zaia, MA Gutierrez-Franco… - Communications …, 2024 - nature.com
Background Although the mpox global health emergency caused by mpox virus (MPXV)
clade IIb. 1 has ended, mpox cases are still reported due to low vaccination coverage and …

Progress in the evaluation of modified vaccinia Ankara vaccine against mpox

V Mazzotta, G Matusali, A Oliva, F Maggi… - The Lancet Infectious …, 2023 - thelancet.com
Vaccination is one of the tools used against the 2022 outbreak of mpox (formerly known as
monkeypox), considered a Public Health Emergency of International Concern by WHO until …

[HTML][HTML] Vaccine effectiveness of 3rd generation mpox vaccines against mpox and disease severity: A systematic review and meta-analysis

L Pischel, BA Martini, N Yu, D Cacesse, M Tracy… - Vaccine, 2024 - Elsevier
Introduction Before the global mpox outbreak which began in 2022, the real-world vaccine
effectiveness (VE) of mpox vaccines was unknown. We quantified the VE in the global …

Complement-dependent mpox-virus-neutralizing antibodies in infected and vaccinated individuals

M Hubert, F Guivel-Benhassine, T Bruel, F Porrot… - Cell Host & Microbe, 2023 - cell.com
Mpox virus (MPXV) caused a multi-country outbreak in non-endemic areas in 2022.
Following historic success of smallpox vaccination with vaccinia virus (VACV)-based …

[HTML][HTML] Safety and efficacy of post-eradication smallpox vaccine as an mpox vaccine: a systematic review with meta-analysis

SM Malone, AK Mitra, NA Onumah, A Brown… - International Journal of …, 2023 - mdpi.com
According to the World Health Organization, 83,339 laboratory-confirmed cases, including
72 deaths, of mpox (formerly known as monkeypox), have been reported from 110 locations …