Coronaviruses (CoVs) cause numerous diseases, including Middle East respiratory
syndrome and severe acute respiratory syndrome, generating significant health-related and …

Nucleocapsid protein (NP), an essential RNA-binding viral protein in human coronavirus
(CoV)-infected cells, is required for the replication and transcription of viral RNA. Recent …

Highlights•Coronavirus nucleocapsid proteins are appealing drug targets against
coronavirus-induced diseases.•A variety of compounds targeting the coronavirus …

The seven pathogenic human coronaviruses (HCoVs) include HCoV-229E, HCoV-OC43,
HCoV-NL63, and HCoV-HKU1, which usually cause mild upper respiratory tract diseases …

Abstract Human coronavirus OC43 (HCoV-OC43) is a causative agent of the common cold.
The nucleocapsid (N) protein, which is a major structural protein of CoVs, binds to the viral …

Coronaviruses are responsible for upper and lower respiratory tract infections in humans. It
is estimated that 1 to 10% of the population suffers annually from cold-like symptoms related …

Structure-based stabilization of protein–protein interactions (PPIs) is a promising strategy for
drug discovery. However, this approach has mainly focused on the stabilization of native …

Abstract COVID‐19, caused by SARS‐CoV‐2, has resulted in severe and unprecedented
economic and social disruptions in the world. Nucleocapsid (N) protein, which is the major …

ADP-ribosylation is a common post-translational modification, although how it modulates
RNA virus infection is not well understood. While screening for ADP-ribosylated proteins …

Nucleocapsid (N) protein plays crucial roles in the life cycle of severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), including the formation of ribonucleoprotein (RNP) …