Imaging Approaches to Investigate Pathophysiological Mechanisms of Brain Disease in Zebrafish

L Turrini, L Roschi, G de Vito, FS Pavone… - International Journal of …, 2023 - mdpi.com
Zebrafish has become an essential model organism in modern biomedical research. Owing
to its distinctive features and high grade of genomic homology with humans, it is increasingly …

Diving into the zebrafish brain: exploring neuroscience frontiers with genetic tools, imaging techniques, and behavioral insights

O Doszyn, T Dulski, J Zmorzynska - Frontiers in Molecular …, 2024 - frontiersin.org
The zebrafish (Danio rerio) is increasingly used in neuroscience research. Zebrafish are
relatively easy to maintain, and their high fecundity makes them suitable for high-throughput …

Zebrafish: an emerging real-time model system to study Alzheimer's disease and neurospecific drug discovery

S Saleem, RR Kannan - Cell death discovery, 2018 - nature.com
Zebrafish (Danio rerio) is emerging as an increasingly successful model for translational
research on human neurological disorders. In this review, we appraise the high degree of …

[HTML][HTML] Zebrafish as a translational neuroscience model: today's science and tomorrow's success

WMY Mohamed, M Ekker - Frontiers in Physiology, 2023 - frontiersin.org
One of the most significant developments in modern science is the rise of translational
medicine. Danio rerio has offered a new venue for important studies, especially in the field of …

Seeing the whole picture: a comprehensive imaging approach to functional mapping of circuits in behaving zebrafish

CE Feierstein, R Portugues, MB Orger - Neuroscience, 2015 - Elsevier
In recent years, the zebrafish has emerged as an appealing model system to tackle
questions relating to the neural circuit basis of behavior. This can be attributed not just to the …

[HTML][HTML] Zebrafish as a model organism for neurodegenerative disease

K Chia, A Klingseisen, D Sieger… - Frontiers in molecular …, 2022 - frontiersin.org
The zebrafish is increasingly recognised as a model organism for translational research into
human neuropathology. The zebrafish brain exhibits fundamental resemblance with human …

Integrative whole-brain neuroscience in larval zebrafish

GC Vanwalleghem, MB Ahrens, EK Scott - Current opinion in neurobiology, 2018 - Elsevier
Highlights•Neural activity can now be recorded in all cells of larval zebrafish
brains.•Neurons involved in sensation, motor control, and learning have been …

[HTML][HTML] Development of a high-throughput tailored imaging method in zebrafish to understand and treat neuromuscular diseases

L Lescouzères, B Bordignon, P Bomont - Frontiers in Molecular …, 2022 - frontiersin.org
The zebrafish (Danio rerio) is a vertebrate species offering multitude advantages for the
study of conserved biological systems in human and has considerably enriched our …

Computational techniques in zebrafish image processing and analysis

S Xia, Y Zhu, X Xu, W Xia - Journal of Neuroscience Methods, 2013 - Elsevier
The zebrafish (Danio rerio) has been widely used as a vertebrate animal model in
neurobiological. The zebrafish has several unique advantages that make it well suited for …

[HTML][HTML] A Critical Review of Zebrafish Neurological Disease Models− 2. Application: Functional and Neuroanatomical Phenotyping Strategies and Chemical Screens

EA Burton, HA Burgess - Oxford open neuroscience, 2023 - academic.oup.com
Extensive phylogenetic conservation of molecular pathways and neuroanatomical
structures, associated with efficient methods for genetic modification, have been exploited …