Squamous cell carcinoma (SCC) is a treatment‐refractory tumour which arises from the
epithelium of diverse anatomical sites such as oesophagus, head and neck, lung and skin …

Our understanding of cancer and the key pathways that drive cancer survival has expanded
rapidly over the past several decades. However, there are still important challenges that …

Head and neck squamous cell carcinoma (HNSCC) and many other epithelial malignancies
exhibit increased proliferation, invasion, and inflammation, concomitant with aberrant …

Abstract Objectives/Hypothesis: p63, a member of the p53 family of genes, is vital for normal
epithelial development and may play a critical role in epithelial tumor formation. Although …

The TP63 is an indispensable transcription factor for development and homeostasis of
epithelia and its derived glandular tissue. It is also involved in female germline cell quality …

ΔNp63α is a member of the p53 family of transcription factors that functions as an oncogene
in squamous cell carcinomas (SCCs). Because ΔNp63α and p53 bind virtually identical …

ΔNp63 is overexpressed in squamous carcinomas where it is associated with proliferation
and is believed to enhance cell growth by blocking p53-mediated transactivation. In normal …

ΔNp63α is a nuclear transcription factor that maintains epithelial progenitor cell populations,
is overexpressed in several epithelial cancers, and can negatively regulate apoptosis …

The last 20 years of research into p53 function has revealed some fascinating discoveries
into the orchestration of tumour suppressor pathways with a multitude of putative drug …

Squamous cell carcinoma (SCC) is an aggressive malignancy that can originate from
various organs. TP63 is a master regulator that plays an essential role in epidermal …