Bone development occurs through a series of synchronous events that result in the
formation of the body scaffold. The repair potential of bone and its surrounding …

Vertebrates evolved elaborating a structure made up of more than 200 bones and cartilages
articulated with one another to form the skeleton, through which locomotion, organ …

Bone homeostasis is securely controlled by the dynamic well‐balanced actions among
osteoclasts, osteoblasts and osteocytes. Osteoclasts are large multinucleated cells that …

The biology of bone healing is a rapidly developing science. Advances in transgenic and
gene‐targeted mice have enabled tissue and cell‐specific investigations of skeletal …

The complexity of fracture repair makes it an ideal process for studying the interplay
between the molecular, cellular, tissue, and organ level events involved in tissue …

Skeletal stem cells confer to bone its innate capacity for regeneration and repair. Bone
regeneration strategies seek to harness and enhance this regenerative capacity for the …

The bone remodelling cycle (see Poster panel “The bone remodelling cycle”) maintains the
integrity of the skeleton through the balanced activities of its constituent cell types. These are …

Medical advances have led to a welcome increase in life expectancy. However,
accompanying longevity introduces new challenges: increases in age-related diseases and …

Bone formation starts near the end of the embryonic stage of development and continues
throughout life during bone modeling and growth, remodeling, and when needed …

The exploration of stem and progenitor cells holds promise for advancing our understanding
of the biology of tissue repair and regeneration mechanisms after injury. This will also help …