Abstract Type 1 diabetes (T1D)—an autoimmune disease that destroys the pancreatic islets,
resulting in insulin deficiency—often begins early in life when islet autoantibody appearance …

Type 1 diabetes (T1D) is an autoimmune disease in which the insulin-producing β cells of
the pancreas are destroyed by T lymphocytes. Recent studies have demonstrated that …

Background Early prediction of childhood type 1 diabetes reduces ketoacidosis at diagnosis
and provides opportunities for disease prevention. However, only highly efficient …

Abstract Development of islet autoimmunity precedes the onset of type 1 diabetes in
children, however, the presence of autoantibodies does not necessarily lead to manifest …

Background Around 0.3% of newborns will develop autoimmunity to pancreatic beta cells in
childhood and subsequently develop type 1 diabetes before adulthood. Primary prevention …

Type 1 diabetes (T1D) is a disease of insulin deficiency that results from autoimmune
destruction of pancreatic islet β cells. The exact cause of T1D remains unknown, although …

Objective Type 1 diabetes can be identified by the presence of beta-cell autoantibodies that
often arise in the first few years of life. The purpose of this perspective is to present the case …

Background Previous studies of type 1 diabetes in childhood and adolescence have found
large variations in reported incidence around the world. However, it is unclear whether these …

OBJECTIVE To combine prospective cohort studies, by including HLA harmonization, and
estimate risk of islet autoimmunity and progression to clinical diabetes. RESEARCH …

Objective To determine whether screening for islet autoantibodies in children prevents
ketoacidosis and other metabolic complications at diabetes onset and improves the clinical …