Silicosis as an occupational lung disease has been present in our lives for centuries.
Research studies have already developed and implemented many animal models to study …

There is some evidence for potential therapeutic targets in silicosis but limited translation
into human studies. Treatment of silicosis likely requires a multimodal approach, and there is …

The clinical, histopathologic, and epidemiologic features of silicosis provide clues to the
mechanisms of the disease. This review presents the concept that interactions between …

Further research on the molecular mechanisms involved in the inflammatory processes
important for progression to fibrotic diseases is needed for the development of effective …

Silicosis is caused by the inhalation of crystalline silica (silicon dioxide, SiO2) in various
forms. This review proposes that the cascade of inflammatory and fibrotic events involved in …

Silicosis is a fatal occupational lung disease which currently has no effective clinical cure.
Recent studies examining the underlying mechanism of silicosis have primarily examined …

Experimental silicosis allows study of the mechanisms of lung injury, inflammation, and
fibrosis. Inbred mice are an attractive species in which to study these mechanisms because …

Silicosis is a disease characterized by extensive lung nodules and fibrosis caused by the
prolonged inhalation of silica in occupational settings. However, the molecular mechanism …

Silicosis, characterized by irreversible pulmonary fibrosis, remains a major global public
health problem. Nowadays, cumulative studies are focusing on elucidating the pathogenesis …

Silicosis provides a good model for chronic interstitial pulmonary inflammation. In order to
clarify the role of mast cells in the development of interstitial lung diseases, silica suspension …