Agent-based models have been employed to describe numerous processes in immunology.
Simulations based on these types of models have been used to enhance our understanding …

Unlike traditional biological research that focuses on a small set of components, systems
biology studies the complex interactions among a large number of genes, proteins, and …

Many pathogens are able to manipulate the signaling pathways responsible for the
generation of host immune responses. Here we examine and model a respiratory infection …

Highlights•Systems Biology Markup Language has greatly improved the dissemination of
many model types.•The representation of agent-based models (ABMs) remains in its infancy …

Pathogenic microorganisms entail enormous problems for humans, livestock, and crop
plants. A better understanding of the different infection strategies of the pathogens enables …

Agent-based simulation modelling has been used in many epidemiological studies on
infectious diseases. However, because agent based modelling is a field without any clear …

Several components that interact with each other to evolve a complex, and, in some cases,
unexpected behavior, represents one of the main and fascinating features of the mammalian …

Understanding the mechanisms governing host-pathogen kinetics is important and can
guide human interventions. In-host mathematical models, together with biological data, have …

The immune system is inordinately complex with many interacting components determining
overall outcomes. Mathematical and computational modelling provides a useful way in …

Abstract Background We introduce the Basic Immune Simulator (BIS), an agent-based
model created to study the interactions between the cells of the innate and adaptive immune …