The identification of patients with coronavirus disease 2019 and high risk of severe disease
is a challenge in routine care. We performed cell phenotypic, serum, and RNA sequencing …

Pathologic immune hyperactivation is emerging as a key feature of critical illness in COVID-
19, but the mechanisms involved remain poorly understood. We carried out proteomic …

We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes
(monocyte CD169 [mCD169]) in 53 adult patients admitted to the hospital during the …

Objectives Critical illness in COVID-19 is attributed to an exaggerated host immune
response. Since neutrophils are the major component of innate immunity, we hypothesize …

Abstract SARS coronavirus 2 (SARS-CoV-2) is a novel viral pathogen that causes a clinical
disease called coronavirus disease 2019 (COVID-19). Although most COVID-19 cases are …

Intensive care unit (ICU) admissions and mortality in severe COVID-19 patients are driven
by “cytokine storms” and acute respiratory distress syndrome (ARDS). Interim clinical trial …

Objectives Emerging evidence of dysregulation of the myeloid cell compartment urges
investigations on neutrophil characteristics in coronavirus disease 2019 (COVID‐19). We …

Objectives: Coronavirus disease 2019 is caused by severe acute respiratory syndrome-
coronavirus-2 infection to which there is no community immunity. Patients admitted to ICUs …

Infection with the SARS-CoV2 virus can vary from asymptomatic, or flu-like with moderate
disease, up to critically severe. Severe disease, termed COVID-19, involves acute …

Background Emerging evidence indicates a potential role for monocytes in COVID-19
immunopathology. We investigated two soluble markers of monocyte activation, sCD14 and …