The global decline in malaria has stalled, emphasizing the need for vaccines that induce
durable sterilizing immunity. Here we optimized regimens for chemoprophylaxis vaccination …

Abstract Immunization with Plasmodium falciparum (Pf) sporozoites under
chemoprophylaxis (PfSPZ-CVac) is the most efficacious approach to malaria vaccination …

A highly protective malaria vaccine would greatly facilitate the prevention and elimination of
malaria and containment of drug-resistant parasites. A high level (more than 90%) of …

Abstract An attenuated Plasmodium falciparum (Pf) sporozoite (SPZ) vaccine, PfSPZ
Vaccine, is highly protective against controlled human malaria infection (CHMI) 3 weeks …

A live-attenuated malaria vaccine, Plasmodium falciparum sporozoite vaccine (PfSPZ
Vaccine), confers sterile protection against controlled human malaria infection (CHMI) with …

Immunization with attenuated Plasmodium sporozoites can induce protection against
malaria infection, as shown by Plasmodium falciparum (Pf) sporozoites attenuated by …

Sanaria Inc. has developed methods to manufacture, purify and cryopreserve aseptic
Plasmodium falciparum (Pf) sporozoites (SPZ), and is using this platform technology to …

Immunization with radiation-attenuated Plasmodium falciparum (Pf) sporozoites (SPZ) in
PfSPZ Vaccine, has provided better vaccine efficacy (VE) against controlled human malaria …

BACKGROUND: A radiation-attenuated Plasmodium falciparum (Pf) sporozoite (SPZ)
malaria vaccine, PfSPZ Vaccine, protected 6 of 6 subjects (100%) against homologous Pf …

An effective vaccine is needed for the prevention and elimination of malaria. The only
immunogens that have been shown to have a protective efficacy of more than 90% against …