The highly transmissible variants of SARS-CoV-2, the causative pathogen of the COVID-19
pandemic, bring new waves of infection worldwide. Identification of effective therapeutic …

The widespread nature of several viruses is greatly credited to their rapidly altering RNA
genomes that enable the infection to persist despite challenges presented by host cells …

COVID-19 respiratory disease caused by the severe acute respiratory syndrome coronavirus-
2 (SARS-CoV-2) has rapidly become a global health issue since it emerged in December …

Abstract The coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), poses an unprecedented global health …

Antiviral therapeutics is one effective avenue to control and end this devastating COVID-19
pandemic. The viral RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 has been …

SARS-CoV-2 (severe acute respiratory syndrome coronavirus‐2), a member of the
coronavirus family, appeared in 2019 and has caused the largest global public health and …

WHO has declared COVID-19 a pandemic, which has affected the whole world and has
caused unprecedented social and economic disruption. Since the emergence of the …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a
worldwide pandemic. The identification of effective antiviral drugs remains an urgent …

ABSTRACT Introduction: The current SARS-CoV-2 pandemic urgently demands for both
prevention and treatment strategies. RNA-dependent RNA-polymerase (RdRp), which has …

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a
worldwide pandemic since 2019, spreading rapidly and posing a significant threat to human …