Genome‐wide association studies have revealed a plethora of genetic variants that
correlate with polygenic conditions. However, causal molecular mechanisms have proven …

In 2007, an association of single nucleotide polymorphisms (SNPs) in the fat mass and
obesity-associated (FTO) gene region with body mass index (BMI) and risk of obesity was …

Genome‐wide association studies have been very powerful, uncovering potentially new
biology that would not have been possible using a candidate gene approach. A prime …

Genome‐wide association, the latest gene‐finding strategy, has led to the first major
success in the field of obesity genetics with the discovery of FTO (fat mass and obesity …

Background: SNPs in the first intron of the fat mass and obesity-associated (FTO) gene
represent the strongest genome-wide associations with adiposity [body mass index (BMI)]; …

Single nucleotide polymorphisms (SNPs) within a genetic region including the first two
introns of the gene encoding FTO have consistently been shown to be the strongest genetic …

Genome-wide association studies (GWAS) identified> 90 loci containing genetic variants,
many in intronic regions, associated with human obesity. Understanding how these variants …

Few would dispute that the current obesity epidemic has been driven by lifestyle and
environmental changes. However, it is clear that individuals respond differently to these …

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Genome-wide association studies revealed that variants within FTO (fat-mass-and obesity-
associated) are strongly associated with obesity susceptibility. A recent study in Nature …