Metabolic syndrome (MetS), ie a cluster of physiological and biochemical abnormalities can
lead to diabetic nephropathy (DN). Insulin resistance, impaired fasting glucose are the main …

Chronic hyperglycemia and oxidative stress in diabetes results in the formation and
accumulation advanced glycation end products (AGEs). AGEs have a wide range of …

Advanced glycation end products (AGEs) are a heterogeneous group of protein and lipids to
which sugar residues are covalently bound. AGE formation is increased in situations with …

Several factors are incriminated in the genesis of diabetic nephropathy (DN). To elucidate
their interplays, we utilized a diabetic rat model with nephropathy (SHR/NDmcr-cp). This …

Diabetic nephropathy is currently the single largest cause of endstage renal disease (ESRD)
in the United States and many European countries. The primary cause for the development …

About 246 million people worldwide had diabetes in 2007. The global figure of people with
diabetes is projected to increase to 370 million in 2030. As the prevalence of diabetes has …

Glycation is the process whereby sugars bind to the free amine residues of proteins. These
newly formed modified molecular species are known as 'advanced glycation end-products' …

Diabetes is the major cause of chronic kidney disease which in turn may lead to end-stage
renal disease (ESRD) ending up in dialysis. Hemodynamic and structural changes following …

In 2007, diabetes affected around 244 million people across the globe. The number of
diabetics worldwide is projected to reach 370 million by 2030. With diabetes incidence …

Nonenzymatic reactions between sugars and the free amino groups on proteins, lipids, and
nucleic acids result in molecular dysfunction through the formation of advanced glycation …