Human female fertility and reproductive lifespan decrease significantly with age, resulting in
an extended post-reproductive period. The central dogma in human female reproduction …

Studies of human oocytes obtained from women of advanced reproductive age revealed that
spindles are frequently aberrant, with chromosomes sometimes failing to align properly at …

It is well documented that female fertility is decreased with advanced maternal age due to
chromosome abnormality in oocytes. Increased chromosome missegregation is mainly …

During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

Chromosome segregation errors in human oocytes lead to aneuploid embryos that cause
infertility and birth defects. Here we provide an overview of the chromosome-segregation …

BACKGROUND Meiotic chromosome segregation in human oocytes is notoriously error-
prone, especially with ageing. Such errors markedly reduce the reproductive chances of …

The age‐associated decline in female fertility is largely ascribable to a decrease in oocyte
quality. This phenomenon is multifaceted and influenced by numerous interconnected …

Ovarian aging in women correlates with the progressive loss of both the number and quality
of oocytes. When these processes occur early or are accelerated, their clinical correlates are …

Aneuploidy in human eggs increases with maternal age and can result in infertility,
miscarriages, and birth defects. The molecular mechanisms leading to aneuploidy, however …

Human eggs frequently contain an incorrect number of chromosomes, a condition termed
aneuploidy. Aneuploidy affects∼ 10–25% of eggs in women in their early 30s, and more …