Pacemaker cells are the basis of rhythm in the heart. Cardiovascular diseases, and in
particular, arrhythmias are a leading cause of hospital admissions and have been implicated …

Hyperpolarization and Cyclic Nucleotide (HCN)-gated channels represent the molecular
correlates of the “funny” pacemaker current (If), a current activated by hyperpolarization and …

The current produced by hyperpolarization-activated cyclic nucleotide-gated (HCN)
channels (termed I f, cardiac pacemaker “funny” current, and I h in neurons) is also …

The hyperpolarization-activated cyclic-nucleotide-gated (HCN) proteins are voltage-
dependent ion channels, conducting both Na+ and K+, blocked by millimolar concentrations …

The hyperpolarization-activated cyclic nucleotide-gated (HCN) channels play an important
role in the generation of pacemaker activity of cardiac sinoatrial node cells and immature …

Higher heart rate (HR) is independently related to worse outcomes in various cardiac
diseases, including hypertension, coronary artery disease, and heart failure (HF). HR is …

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are reverse voltage-
dependent, and their activation depends on the hyperpolarization of the membrane and may …

Hyperpolarization-activated cyclic nucleotide gated (HCN) channels pass a cationic current
(Ih/If) that crucially contributes to the slow diastolic depolarization (SDD) of sinoatrial …

The pacemaker channel isoforms are encoded by the hyperpolarization-activated and cyclic
nucleotide-gated (HCN) gene family and are responsible for diverse cellular functions …

Hyperpolarization‐activated cation channels generate the If current in the heart. In the sino‐
atrial node (SAN), If is thought to play an essential role in setting the heart rate and …