Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Cardiovascular diseases are the most prominent maladies in aging societies. Indeed, aging
promotes the structural and functional declines of both the heart and the blood circulation …

Recent advances in health care have improved the management of cardiometabolic
disorders, and prolonged lifespan. However, the ever-rising prevalence of metabolic stress …

The world's population over 60 years is growing rapidly, reaching 22% of the global
population in the next decades. Despite the increase in global longevity, individual …

As the elderly segment of the world population increases, it is critical to understand the
changes in cardiac structure and function during the normal aging process. In this review …

Age is one of the major risk factors associated with cardiovascular disease (CVD). About
one‐fifth of the world population will be aged 65 or older by 2030, with an exponential …

Cardiac ageing manifests as a decline in function leading to heart failure. At the cellular
level, ageing entails decreased replicative capacity and dysregulation of cellular processes …

Cardiovascular disease is the leading cause of morbidity and mortality worldwide.
Advancing age is a major risk factor for developing cardiovascular disease because of the …

Aging, an irreversible biological process, serves as an independent risk factor for chronic
disease including cancer, pulmonary, neurodegenerative, and cardiovascular diseases. In …

The two primary molecular regulators of lifespan are sirtuin-1 (SIRT1) and mammalian target
of rapamycin complex 1 (mTORC1). Each plays a central role in two highly interconnected …