Cordycepin (COR) and pentostatin (PTN) are adenosine analogs with related bioactivity
profiles as both mimic adenosine and can inhibit some of the processes that are adenosine …

Cordycepin (3′-deoxyadenosine), a cytotoxic nucleoside analogue found in Cordyceps
militaris, has attracted much attention due to its therapeutic potential and biological value …

Tetramic acid containing a decalin ring such as equisetin and phomasetin is one of the
characteristic scaffolds found in fungal bioactive secondary metabolites. Polyketide (PKS) …

Equisetin synthetase (EqiS), from the filamentous fungus Fusarium heterosporum ATCC
74349, was initially assigned on the basis of genetic knockout and expression analysis …

Linking bioactive compounds to their cellular targets is a central challenge in chemical
biology. Here we report the mode of action of theonellamides, bicyclic peptides derived from …

The tenS gene encoding tenellin synthetase (TENS), a 4239‐residue polyketide synthase
nonribosomal‐peptide synthetase (PKS‐NRPS) from Beauveria bassiana, was expressed in …

Ascomycete Cordyceps fungi such as C. militaris, C. cicadae, and C. guangdongensis have
been mass produced on artificial media either as food supplements or health additives while …

Filamentous fungi are renowned for the production of bioactive secondary metabolites.
Typically, one distinct metabolite is generated from a specific secondary metabolite cluster …

Endocrocin is a simple anthraquinone frequently identified in extracts of numerous fungi.
Several biosynthetic schemes for endocrocin synthesis have been hypothesized, but to date …

Teleocidin B is an indole terpenoid isolated from Streptomyces. Due to its unique chemical
structure and ability to activate protein kinase C, it has attracted interest in the areas of …