[HTML][HTML] Manipulation of innate immune signaling pathways by SARS-CoV-2 non-structural proteins

Y Lu, HA Michel, PH Wang, GL Smith - Frontiers in Microbiology, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the
current coronavirus disease 2019 (COVID-19) pandemic, induces an unbalanced immune …

[HTML][HTML] SARS-CoV-2 non-structural proteins and their roles in host immune evasion

ZY Low, NZ Zabidi, AJW Yip, A Puniyamurti, VTK Chow… - Viruses, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) has caused an unprecedented global crisis and
continues to threaten public health. The etiological agent of this devastating pandemic …

[HTML][HTML] Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

M Hayn, M Hirschenberger, L Koepke, R Nchioua… - Cell reports, 2021 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades most innate
immune responses but may still be vulnerable to some. Here, we systematically analyze the …

[HTML][HTML] All hands on deck: SARS-CoV-2 proteins that block early anti-viral interferon responses

AC Setaro, MM Gaglia - Current research in virological science, 2021 - Elsevier
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is responsible for
the current pandemic coronavirus disease of 2019 (COVID-19). Like other pathogens, SARS …

[HTML][HTML] SARS-CoV-2 viral proteins NSP1 and NSP13 inhibit interferon activation through distinct mechanisms

C Vazquez, SE Swanson, SG Negatu, M Dittmar… - PloS one, 2021 - journals.plos.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a devastating
global pandemic, infecting over 43 million people and claiming over 1 million lives, with …

[HTML][HTML] Activation and evasion of type I interferon responses by SARS-CoV-2

X Lei, X Dong, R Ma, W Wang, X Xiao, Z Tian… - Nature …, 2020 - nature.com
The pandemic of COVID-19 has posed an unprecedented threat to global public health.
However, the interplay between the viral pathogen of COVID-19, SARS-CoV-2, and host …

[HTML][HTML] Roles and functions of SARS-CoV-2 proteins in host immune evasion

F Rashid, Z Xie, M Suleman, A Shah, S Khan… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evades the host immune
system through a variety of regulatory mechanisms. The genome of SARS-CoV-2 encodes …

[HTML][HTML] A dual-role of SARS-CoV-2 nucleocapsid protein in regulating innate immune response

Y Zhao, L Sui, P Wu, W Wang, Z Wang, Y Yu… - … and Targeted Therapy, 2021 - nature.com
The recently emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
which is the causative agent of ongoing global pandemic of COVID-19, may trigger …

SARS-CoV-2 nonstructural protein 1 inhibits the interferon response by causing depletion of key host signaling factors

A Kumar, R Ishida, T Strilets, J Cole… - Journal of …, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the ongoing coronavirus disease 2019 (COVID-19) pandemic. While previous studies have …

[HTML][HTML] The molecular mechanism of SARS-CoV-2 evading host antiviral innate immunity

W Gu, H Gan, Y Ma, L Xu, ZJ Cheng, B Li, X Zhang… - Virology journal, 2022 - Springer
Abstract The newly identified Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV-2) has resulted in a global health emergency (COVID-19) because of its rapid spread …