According to classical thermodynamics, biological ligand− receptor bonds should have a
median lifetime of about 2 ms, and nearly half should have lifetimes of nanoseconds to …

Interactions between surface-anchored receptors and ligands mediate cell–cell and cell–
environment communications in many biological processes. Molecular interactions across …

The binding properties of biomolecules play a crucial role in many biological phenomena,
especially cell adhesion. Whereas the attachment kinetics of soluble proteins is considered …

We describe a new method for determining receptor-ligand association/dissociation events
across the interface of two surfaces (two-dimensional binding) by monitoring abrupt …

Beyond covalent connections within protein and lipid molecules, weak noncovalent
interactions between large molecules govern properties of cellular structure and interfacial …

Weak non-covalent interactions between large molecules govern interfacial structure and
adhesion in biology. Because of thermal activation, these bonds have modest lifetimes and …

Ligands mounted to surfaces via extensible tethers are present in nature and represent a
growing class of molecules used to engineer adhesion in drug targeting, biosensing, self …

Cell adhesion is mediated by numerous membrane receptors. It is desirable to derive the
outcome of a cell-surface encounter from the molecular properties of interacting receptors …

Cell-adhesion molecules (CAMs) often exist as homodimers under physiological conditions.
However, owing to steric hindrance, simultaneous binding of two ligands to the homodimers …

Substantial experimental evidence indicates that the mechanical force applied to pull apart
non-covalent molecular bonds (such as receptor− ligand pairs) can significantly decrease …