Beyond 20 in the 21st century: prospects and challenges of non-canonical amino acids in peptide drug discovery
JL Hickey, D Sindhikara, SL Zultanski… - ACS Medicinal …, 2023 - ACS Publications
Life is constructed primarily using a toolbox of 20 canonical amino acids─ relying upon
these building blocks for the assembly of proteins and peptides that regulate nearly every …
these building blocks for the assembly of proteins and peptides that regulate nearly every …
Exploring sequence space: harnessing chemical and biological diversity towards new peptide leads
R Obexer, LJ Walport, H Suga - Current opinion in chemical biology, 2017 - Elsevier
Highlights•Peptides now represent an expanding class of novel drugs.•They are ideal
candidates for pooled library screening approaches.•Technologies such as SICLOPPS …
candidates for pooled library screening approaches.•Technologies such as SICLOPPS …
Therapeutic applications of an expanded genetic code
SB Sun, PG Schultz, CH Kim - ChemBioChem, 2014 - Wiley Online Library
To date, over 100 noncanonical amino acids (ncAAs) have been genetically encoded in
living cells in order to expand the functional repertoire of the canonical 20 amino acids. More …
living cells in order to expand the functional repertoire of the canonical 20 amino acids. More …
Engineering enzymes for noncanonical amino acid synthesis
The standard proteinogenic amino acids grant access to a myriad of chemistries that
harmonize to create life. Outside of these twenty canonical protein building blocks are …
harmonize to create life. Outside of these twenty canonical protein building blocks are …
Future prospects for noncanonical amino acids in biological therapeutics
Highlights•Use of noncanonical amino acid (ncAAs) in therapeutics requires careful
evaluation.•NcAA-mediated strategies enable important routes to precisely defined …
evaluation.•NcAA-mediated strategies enable important routes to precisely defined …
Technologies for the synthesis of mRNA-encoding libraries and discovery of bioactive natural product-inspired non-traditional macrocyclic peptides
K Ito, T Passioura, H Suga - Molecules, 2013 - mdpi.com
In this review, we discuss emerging technologies for drug discovery, which yields novel
molecular scaffolds based on natural product-inspired non-traditional peptides expressed …
molecular scaffolds based on natural product-inspired non-traditional peptides expressed …
Combining Chemical Protein Synthesis and Random Nonstandard Peptides Integrated Discovery for Modulating Biological Processes
Conspectus Chemical manipulation of naturally occurring peptides offers a convenient route
for generating analogs to screen against different therapeutic targets. However, the limited …
for generating analogs to screen against different therapeutic targets. However, the limited …
Unusual amino acids in medicinal chemistry
MAT Blaskovich - Journal of medicinal chemistry, 2016 - ACS Publications
Unusual amino acids are fundamental building blocks of modern medicinal chemistry. The
combination of readily functionalized amine and carboxyl groups attached to a chiral central …
combination of readily functionalized amine and carboxyl groups attached to a chiral central …
Guiding principles for peptide nanotechnology through directed discovery
Life's diverse molecular functions are largely based on only a small number of highly
conserved building blocks–the twenty canonical amino acids. These building blocks are …
conserved building blocks–the twenty canonical amino acids. These building blocks are …
Prospects of In vivo Incorporation of Non-canonical Amino Acids for the Chemical Diversification of Antimicrobial Peptides
T Baumann, JH Nickling, M Bartholomae… - Frontiers in …, 2017 - frontiersin.org
The incorporation of non-canonical amino acids (ncAA) is an elegant way for the chemical
diversification of recombinantly produced antimicrobial peptides (AMPs). Residue-and site …
diversification of recombinantly produced antimicrobial peptides (AMPs). Residue-and site …