Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis

R Fan, J Sui, X Dong, B Jing, Z Gao - Free Radical Biology and Medicine, 2021 - Elsevier
Acute pancreatitis (AP) is an inflammatory disorder associated with multiple organ failure.
Pyroptosis and ferroptosis are two newly recognized cell death, and whether pyroptosis and …

Gingerenone A Alleviates Ferroptosis in Secondary Liver Injury in Colitis Mice via Activating Nrf2–Gpx4 Signaling Pathway

Y Chen, S Zhu, Z Chen, Y Liu, C Pei… - Journal of Agricultural …, 2022 - ACS Publications
Patients with ulcerative colitis (UC) have been found to be frequently associated with
secondary liver injury (SLI). In this study, we investigated the protective effect of GA on …

Treatment of severe acute pancreatitis and related lung injury by targeting gasdermin D-mediated pyroptosis

J Wu, J Zhang, J Zhao, S Chen, T Zhou… - Frontiers in cell and …, 2021 - frontiersin.org
The functional relevance and effects of the pyroptosis executioner gasdermin D (GSDMD)
on severe acute pancreatitis (SAP)-associated lung injury are unclear. We established …

Ginsenoside Rg3 ameliorates acute pancreatitis by activating the NRF2/HO‑1‑mediated ferroptosis pathway

Y Shan, J Li, A Zhu, W Kong… - … Journal of Molecular …, 2022 - spandidos-publications.com
Acute pancreatitis (AP) is an inflammatory disorder that has been associated with systemic
inflammatory response syndrome. Ginsenoside Rg3 is a major active component of Panax …

Geniposide Possesses the Protective Effect on Myocardial Injury by Inhibiting Oxidative Stress and Ferroptosis via Activation of the Grsf1/GPx4 Axis

Y Shen, X Wang, X Shen, Y Wang, S Wang… - Frontiers in …, 2022 - frontiersin.org
Reactive oxygen species (ROS) produced in the ischemic myocardium can induce
cardiomyocyte injury and death, resulting in cardiac remodeling. Ferroptosis, known as a …

Xanthohumol ameliorates drug-induced hepatic ferroptosis via activating Nrf2/xCT/GPX4 signaling pathway

Y Deng, X Chu, Q Li, G Zhu, J Hu, J Sun, H Zeng… - Phytomedicine, 2024 - Elsevier
Background As a canonical iron-dependent form of regulated cell death (RCD), ferroptosis
plays a crucial role in chemical-induced liver injuries. Previous studies have demonstrated …

Gossypol acetic acid attenuates cardiac ischemia/reperfusion injury in rats via an antiferroptotic mechanism

JH Lin, KT Yang, PC Ting, YP Luo, DJ Lin, YS Wang… - Biomolecules, 2021 - mdpi.com
Myocardial ischemia/reperfusion (I/R) injury has been associated with ferroptosis, which is
characterized by an iron-dependent accumulation of lipid peroxide to lethal levels. Gossypol …

Maresin1 protect against ferroptosis-induced liver injury through ROS inhibition and Nrf2/HO-1/GPX4 activation

W Yang, Y Wang, C Zhang, Y Huang, J Yu… - Frontiers in …, 2022 - frontiersin.org
Drugs, viruses, and chemical poisons stimulating live in a short period of time can cause
acute liver injury (ALI). ALI can further develop into serious liver diseases such as cirrhosis …

Wogonoside attenuates liver fibrosis by triggering hepatic stellate cell ferroptosis through SOCS1/P53/SLC7A11 pathway

G Liu, C Wei, S Yuan, Z Zhang, J Li… - Phytotherapy …, 2022 - Wiley Online Library
Wogonoside (WG) is a flavonoid chemical component extracted from Scutellaria baicalensis,
which exerts therapeutic effects on liver diseases. Ferroptosis, a novel form of programmed …

Zerumbone exhibit protective effect against zearalenone induced toxicity via ameliorating inflammation and oxidative stress induced apoptosis

HM AbuZahra, P Rajendran, MB Ismail - Antioxidants, 2021 - mdpi.com
Zearalenone are widely occurring food contaminants that cause hepatotoxicity. This
research work aimed to investigate how zerumbone, a plant-derived dietary compound, can …