The guanosine analog AT-527 represents a promising candidate against Severe Acute
Respiratory Syndrome coronavirus type 2 (SARS-CoV-2). AT-527 recently entered phase III …

SARS‐CoV‐2 virus has triggered a global pandemic with devastating consequences. The
understanding of fundamental aspects of this virus is of extreme importance. In this work, we …

SARS-CoV-2 is a positive-sense RNA virus responsible for the Coronavirus Disease 2019
(COVID-19) pandemic, which continues to cause significant morbidity, mortality and …

The COVID-19 pandemic caused by nonstop infections of SARS-CoV-2 has continued to
ravage many countries worldwide. Here we report that suramin, a 100-year-old drug, is a …

The catalytic subunit of SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) contains
two active sites that catalyze nucleotidyl-monophosphate transfer (NMPylation). Mechanistic …

Abstract A novel coronavirus (2019-nCoV) outbreak has caused a global pandemic resulting
in tens of thousands of infections and thousands of deaths worldwide. The RNA-dependent …

Decoration of cap on viral RNA plays essential roles in SARS-CoV-2 proliferation. Here, we
report a mechanism for SARS-CoV-2 RNA capping and document structural details at …

Abstract SARS-CoV-2, a member of the coronavirus family, is responsible for the current
COVID-19 worldwide pandemic. We previously demonstrated that five nucleotide analogues …

Replication of the∼ 30 kb-long coronavirus genome is mediated by a complex of non-
structural proteins (NSP), in which NSP7 and NSP8 play a critical role in regulating the RNA …

High-fidelity replication of the large RNA genome of coronaviruses (CoVs) is mediated by a
3′-to-5′ exoribonuclease (ExoN) in nonstructural protein 14 (nsp14), which excises …