Bone metastasis primarily occurs when breast, prostate, or lung cancers disseminate
tumoral cells into bone tissue, leading to a range of complications in skeletal tissues and, in …

Simple Summary Breast cancer commonly migrates to the skeleton. Once patients have
breast cancer in their bones, their quality of life is poor. Research has shown that the …

Simple Summary Three-dimensional bioprinting is a promising tool for the study of cancer
development and progression in bone, as it permits modeling the complexity of the …

Malignant bone tumors are aggressive neoplasms which arise from bone tissue or as a
result of metastasis. The most prevalent types of cancer, such as breast, prostate, and lung …

Cancer metastasis to bone is a three-dimensional (3D), multistep, dynamic process that
requires the sequential involvement of three microenvironments, namely, the primary tumour …

In recent years, tissue engineering approaches have attracted substantial attention owing to
their ability to create physiologically relevant in vitro disease models that closely mimic in …

Bone is the most frequent metastasis site for breast cancer. As well as dramatically
increasing disease burden, bone metastases are also an indicator of poor prognosis. One of …

One of the major limitations of studying cancer-bone metastasis has been the lack of an
appropriate ex-vivo model which can be used under defined conditions that simulates …

The low occurrence rate of bone cancer contributes to delayed diagnosis and treatment; in
addition, the surgical resection of bone tumors can cause significant bone defects, further …

Breast cancer (BrCa) is the second commonest cause of cancer-related deaths in women.
The metastatic breast cancer exhibits a high affinity to bone, leading to debilitating skeletal …