The development and progression of hepatocellular carcinoma (HCC) are dependent on its
local microenvironment. Hypoxia and inflammation are two critical factors that shape the …

Portal vein tumor thrombosis (PVTT) is a significant risk factor for metastasis in
hepatocellular carcinoma (HCC) patients and is therefore associated with poor prognosis …

Hypoxia is known to promote malignant progression and to induce chemoresistance in
cancer. However, the exact mechanisms driving hypoxia induced malignance remain …

Background/Aims: Hypoxic microenvironment, a common feature of hepatocellular
carcinoma (HCC), can induce HIF-1α expression and promote the epithelial-mesenchymal …

The liver has strong innate immunity to counteract pathogens from the gastrointestinal tract.
During the development of liver cancer, which is typically driven by chronic inflammation, the …

Hepatocellular carcinoma (HCC) is one of the most common and aggressive human cancers
worldwide. HCC is an example of inflammation‐related cancer and represents a paradigm …

Abstract Purpose: Hypoxia-inducible factor-2α (HIF2α) is regarded as a preferential target for
individualized hepatocellular carcinoma (HCC) treatment and sorafenib resistance. Our …

Hypoxia‐inducible factors (HIFs) provoke adaptation to hypoxic stress occurring in rapidly
growing tumor tissues. Therefore, overexpression of HIF‐1 or HIF‐2 is a common feature in …

Hypoxia-inducible factor 1α (HIF-1α) and HIF-2α display unique and sometimes opposing
activities in regulating cellular energy homeostasis, cell fate decisions, and oncogenesis …

Hypoxia is a common feature of many solid tumors, including hepatocellular carcinoma
(HCC). Hypoxia can promote tumor progression and induce radiation and chemotherapy …