In yeast, telomere position effect (TPE) results in the reversible silencing of genes near
telomeres. Here we demonstrate the presence of TPE in human cells. HeLa clones …

Reversible transcriptional silencing of genes located near telomeres, termed the telomere
position effect (TPE), is well characterized in Saccharomyces cerevisiae. TPE has also been …

Telomeres, the natural ends of linear eukaryotic chromosomes, are essential for
chromosome stability. Because of the nature of DNA replication, telomeres require a …

Telomeres are the natural ends of eukaryotic chromosomes. In most organisms, telomeres
consist of simple, repeated DNA with the strand running 5′ to 3′ towards the end of the …

In the yeast Saccharomyces cerevisiae, telomere elongation is negatively regulated by the
telomere repeat-binding protein Rap1p, such that a narrow length distribution of telomere …

Telomeres are the protein-DNA structures at the ends of eukaryotic chromosomes. In yeast,
and probably most other eukaryotes, telomeres are essential. They allow the cell to …

The telomerase ribonucleoprotein has a phylogenetically divergent RNA subunit, which
contains a short template for telomeric DNA synthesis. To understand how telomerase RNA …

The CDC13 gene has previously been implicated in the maintenance of telomere integrity in
Saccharomyces cerevisiae. With the use of two classes of mutations, here it is shown that …

In Saccharomyces cerevisiae, the telomerase components Est2p, TLC1 RNA, Est1p, and
Est3p are thought to form a complex that acts late during chromosome replication (S phase) …

Telomeres are multifunctional elements that shield chromosome ends from degradation and
end-to-end fusions, prevent activation of DNA damage checkpoints, and modulate the …