During routine genome duplication, many potential replication origins remain inactive or
'dormant'. Such origin dormancy is achieved, in part, by an interaction with the metabolic …

Chromatin structure affects DNA replication patterns, but the role of specific chromatin
modifiers in regulating the replication process is yet unclear. We report that phosphorylation …

The eukaryotic DNA replication initiation factor Mcm10 is essential for both replisome
assembly and function. Human Mcm10 has two DNA-binding domains, the conserved …

Repetitive DNA sequences within eukaryotic heterochromatin are poorly transcribed and
replicate late in S-phase. In Saccharomyces cerevisiae, the histone deacetylase Sir2 is …

Summary Dbf4-dependent kinases (DDKs) are required for the initiation of DNA replication,
their essential targets being the MCM2-7 proteins. We show that, in Xenopus laevis egg …

SIRT1, the mammalian homolog of yeast Sir2, is a founding member of a family of 7 protein
and histone deacetylases that are involved in numerous biological functions. Previous …

Replication origins are licensed by loading MCM2-7 hexamers before entry into S phase.
However, only∼ 10% of licensed origins are normally used in S phase, with the others …

Sirtuin 2 (SIRT2), is a member of the sirtuin family of NAD+ dependent deacetylases, which
are implicated in diverse biological processes, including metabolism, aging, genome …

A eukaryotic chromosome relies on the function of multiple spatially distributed DNA
replication origins for its stable inheritance. The spatial location of an origin is determined by …

Since the discovery of a yeast gene silencing modifier (Silent Information Modifier 2, SIR2)
and its role in maintaining genomic stability more than two decades ago, SIR2 homologs …