Effect of the glucagon-like peptide-1 receptor agonists semaglutide and liraglutide on kidney outcomes in patients with type 2 diabetes: pooled analysis of SUSTAIN 6 …

AM Shaman, SC Bain, GL Bakris, JB Buse, T Idorn… - Circulation, 2022 - Am Heart Assoc
Background: We assessed the effect of once-weekly semaglutide and once-daily liraglutide
on kidney outcomes in type 2 diabetes. Methods: Pooled (n= 12 637) and by-trial data from …

Potential kidney protection with liraglutide and semaglutide: exploratory mediation analysis

JFE Mann, JB Buse, T Idorn, LA Leiter… - Diabetes, Obesity …, 2021 - Wiley Online Library
Aims To investigate whether effects on chronic kidney disease risk factors could explain the
apparent reduction in kidney outcomes (composite of macroalbuminuria, doubling of serum …

Effects of glucagon‐like peptide‐1 receptor agonists liraglutide and semaglutide on cardiovascular and renal outcomes across body mass index categories in type 2 …

S Verma, DK McGuire, SC Bain… - Diabetes, Obesity …, 2020 - Wiley Online Library
Associations between body mass index (BMI) and the cardiovascular (CV) and kidney
efficacy of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in patients with type 2 …

[HTML][HTML] Post hoc analysis of SUSTAIN 6 and PIONEER 6 trials suggests that people with type 2 diabetes at high cardiovascular risk treated with semaglutide …

KR Tuttle, H Bosch-Traberg, DZI Cherney, S Hadjadj… - Kidney international, 2023 - Elsevier
Glucagon-like peptide-1 receptor agonists reduce albuminuria and may stabilize the
estimated glomerular filtration rate (eGFR) in people with type 2 diabetes (T2D). In this post …

The rationale, design and baseline data of FLOW, a kidney outcomes trial with once-weekly semaglutide in people with type 2 diabetes and chronic kidney disease

P Rossing, FMM Baeres, G Bakris… - Nephrology Dialysis …, 2023 - academic.oup.com
Background Chronic kidney disease (CKD) is a common complication of type 2 diabetes
(T2D). Glucagon-like peptide-1 receptor agonists (GLP-1RAs) improve glycaemic control …

[HTML][HTML] Effects of glycaemic management on diabetic kidney disease

RJ MacIsaac, G Jerums, EI Ekinci - World journal of diabetes, 2017 - ncbi.nlm.nih.gov
Hyperglycaemia contributes to the onset and progression of diabetic kidney disease (DKD).
Observational studies have not consistently demonstrated a glucose threshold, in terms of …

Glucagon-like peptide 1 receptor agonist (GLP-1 RA): long-term effect on kidney function in patients with type 2 diabetes

BJ Von Scholten, TW Hansen, JP Goetze… - Journal of Diabetes and …, 2015 - Elsevier
Aims In a short-term study including 31 patients with type 2 diabetes, glucagon-like peptide
1 receptor agonist (GLP-1 RA) treatment was associated with a significant reversible decline …

[HTML][HTML] Liraglutide and renal outcomes in type 2 diabetes

JFE Mann, DD Ørsted, K Brown-Frandsen… - … England Journal of …, 2017 - Mass Medical Soc
Background In a randomized, controlled trial that compared liraglutide, a glucagon-like
peptide 1 analogue, with placebo in patients with type 2 diabetes and high cardiovascular …

Effects of liraglutide versus placebo on cardiovascular events in patients with type 2 diabetes mellitus and chronic kidney disease: results from the LEADER trial

JFE Mann, V Fonseca, O Mosenzon, I Raz… - Circulation, 2018 - Am Heart Assoc
Background: LEADER trial (Liraglutide Effect and Action in Diabetes: Evaluation of CV
Outcome Results) results demonstrated cardiovascular benefits for patients with type 2 …

Effects of semaglutide on chronic kidney disease in patients with type 2 diabetes

V Perkovic, KR Tuttle, P Rossing… - … England Journal of …, 2024 - Mass Medical Soc
Background Patients with type 2 diabetes and chronic kidney disease are at high risk for
kidney failure, cardiovascular events, and death. Whether treatment with semaglutide would …