ROF‐2 as an Aggregation‐Induced Emission (AIE) Probe for Multi‐Target Amyloid Detection and Screening of Amyloid Inhibitors

Y Tang, D Zhang, J Zheng - Small, 2024 - Wiley Online Library
Misfolding and aggregation of amyloid peptides into β‐structure‐rich fibrils represent pivotal
pathological features in various neurodegenerative diseases, including Alzheimer's disease …

[HTML][HTML] Multi-target amyloid probing and inhibition using basic orange fluorescence

Y Tang, D Zhang, X Gong, J Zheng - Sensors & Diagnostics, 2023 - pubs.rsc.org
Misfolding and aggregation of amyloid peptides are critical pathological events in numerous
protein misfolding diseases (PMDs), such as Alzheimer's disease (AD), type II diabetes …

[HTML][HTML] based electrochemiluminescence sensor for highly sensitive detection of amyloid-β oligomerization: Toward potential diagnosis of Alzheimer's disease

H Liu, X Zhou, Q Shen, D Xing - Theranostics, 2018 - ncbi.nlm.nih.gov
Abstract Development of a rapid and sensitive method for Aβ (1-42) aggregation detection is
of great importance to overcome the limitations of conventional techniques. In this study, we …

Luminometric nanoparticle-based assay for high sensitivity detection of β-amyloid aggregation

S Pihlasalo, T Deguchi, M Virtamo, J Jacobino… - Analytical …, 2017 - ACS Publications
A nanoparticle-based assay utilizing time-resolved luminescence resonance energy transfer
(TR-LRET) was developed for the detection of β-amyloid aggregation. The assay is based …

Translational opportunities for amyloid-targeting fluorophores

KJ Cao, J Yang - Chemical Communications, 2018 - pubs.rsc.org
Advances in diagnostic medicine have led to an increased awareness and heightened
concern for the high prevalence of amyloid-associated neurodegenerative diseases …

[HTML][HTML] A high affinity red fluorescence and colorimetric probe for amyloid β aggregates

K Rajasekhar, N Narayanaswamy, NA Murugan… - Scientific reports, 2016 - nature.com
A major challenge in the Alzheimer's disease (AD) is its timely diagnosis. Amyloid β (Aβ)
aggregates have been proposed as the most viable biomarker for the diagnosis of AD. Here …

General aggregation-induced emission probes for amyloid inhibitors with dual inhibition capacity against amyloid β-protein and α-synuclein

L Jia, W Wang, Y Yan, R Hu, J Sang… - … applied materials & …, 2020 - ACS Publications
Amyloid self-assembly is pathologically linked to many neurodegenerative diseases,
including Alzheimer's disease (AD) and Parkinson's disease (PD). While many inhibitors …

Current advancements in Aβ luminescent probes and inhibitors of Aβ aggregation

DL Ma, D Shiu-Hin Chan, V Pui-Yan Ma… - Current Alzheimer …, 2012 - ingentaconnect.com
Alzheimer's disease (AD) is a neurodegenerative disorder that severely jeopardizes the
health of aging populations all over the world. According to the amyloid cascade hypothesis …

Advances in fluorescent probes for detection and imaging of amyloid-β peptides in Alzheimer's disease

Y Zhang, C Ding, C Li, X Wang - Advances in Clinical Chemistry, 2021 - Elsevier
Amyloid plaques generated from the accumulation of amyloid-β peptides (Aβ) fibrils in the
brain is one of the main hallmarks of Alzheimer's disease (AD), a most common …

Targeting β-amyloid plaques and oligomers: development of near-IR fluorescence imaging probes

H Liu, J Yang, L Wang, Y Xu, S Zhang, J Lv… - Future Medicinal …, 2017 - Taylor & Francis
Evidence indicated that shifting treatment to a presymptomatic stage may produce significant
benefits to prevent/alleviate the progression of Alzheimer's disease (AD); in particular, early …