The human gut microbiome is a collection of bacteria, protozoa, fungi, and viruses that
coexist in our bodies and are essential in protective, metabolic, and physiologic functions of …

The gut microbiota changes with age, but it is not clear to what degree these changes are
due to physiologic changes, age-associated inflammation or immunosenescence, diet …

The gut microbiota shows a wide inter-individual variation, but its within-individual variation
is relatively stable over time. A functional core microbiome, provided by abundant bacterial …

Chronic inflammation represents one of the most consistent biologic features of aging.
However, the precise etiology of persistent low-grade increases in inflammation remains …

Revolutionary advancements of high-throughput sequencing and metagenomic tools have
provided new insights to microbiome function, including a bidirectional relationship between …

The significance of diversity, composition, and functional attributes of the gut microbiota in
shaping human health is well recognized. Studies have shown that gut microbiota is closely …

Aging is characterized by the functional decline of tissues and organs and increased risk of
aging-associated disorders, which pose major societal challenges and are a public health …

The gut microbiome is a contributory factor in ageing-related health loss and in several non-
communicable diseases in all age groups. Some age-linked and disease-linked …

The microbiome plays a fundamental role in the maturation, function, and regulation of the
host-immune system from birth to old age. In return, the immune system has co-evolved a …

Extrinsic factors, such as lifestyle and diet, are shown to be essential in the control of human
healthy aging, and thus, longevity. They do so by targeting at least in part the gut …