The diversity of distinct covalent forms of proteins (the proteome) greatly exceeds the
number of proteins predicted by DNA coding capacities owing to directed posttranslational …

Post-translational modifications modulate the activity of most eukaryote proteins. Analysis of
these modifications presents formidable challenges but their determination generates …

A large array of posttranslational modifications can dramatically change the properties of
proteins and influence different aspects of their biological function such as enzymatic …

The number of protein isoforms in proteomes can be two to three orders of magnitude higher
than the number of genes in the genomes. This is in large part due to posttranslational …

Recently produced information on post-translational modifications makes it possible to
interpret their biological regulation with new insights. Various protein modifications finely …

Proteins carry out a wide variety of catalytic, regulatory, signalling and structural functions in
living systems. Following their assembly on ribosomes and throughout their lifetimes, most …

Most biological processes are regulated by post-translational modifications of proteins, and
conditions that disrupt the regulation of such events can lead to disease. In the past decade …

Post-translational modifications of proteins control many biological processes, and
examining their diversity is critical for understanding mechanisms of cell regulation. Mass …

Posttranslational modifications of proteins possess key functions in the regulation of various
cellular processes. While they facilitate fast, location-specific and transient reactions to …

Post-translational modifications generate tremendous diversity, complexity and
heterogeneity of gene products, and their determination is one of the main challenges in …