Objective. To summarize current concepts on neuroendocrine and genetic principles
underlying stress-related depression and to discuss the challenges of personalized …

Vulnerability to depression has been linked to the interaction of genetic predisposition with
stressful life events. This review considers the associations between serotonergic and …

Clear evidence has linked dysregulated hypothalamus–pituitary–adrenocortical (HPA) axis
function to the aetiology and pathophysiology of major depression (MD), as observed in the …

An endophenotypic approach in the research of major depression (MDD) has the potential
to enlarge our understanding of the neurobiology and genetics of this complex disease. It …

The role of stress in the origin and development of depression may be conceived as the
result of multiple converging factors, including the chronic effect of environmental stressors …

Publisher Summary The chapter discusses the role of genes in the etiology of mood
disorders. The effects of genes may be direct and indirect such as modulation of the effects …

Genetic variation underlying hypothalamic pituitary adrenal (HPA) axis overactivity in
healthy controls (HCs) and patients with severe forms of major depression has not been well …

Objectives The stress response is related to both physiological and psychological factors
and is strongly marked by a neuroendocrine component. Genetic factors are believed to …

The aim of the present review was to present clinical aspects of recent research in genes,
the experience of stressful life events and depression. 60-70% experience a moderate to …

The risk for neuropsychiatric illnesses has a strong sex bias, and for major depressive
disorder (MDD), females show a more than 2-fold greater risk compared to males. Such …