The molecular underpinnings of the uncontrolled release of proinflammatory cytokines and
chemokines ('cytokine storm'), which can cause organ damage and even mortality, are not …

Inflammation is a complex, non-linear process central to many of the diseases that affect
both developed and emerging nations. A systems-based understanding of inflammation …

Inflammation is a complex, multiscale biological response to threats–both internal and
external–to the body, which is also required for proper healing of injured tissue. In turn …

Timely resolution of inflammation is critical for the restoration of homeostasis in injured or
infected tissue. Chronic inflammation is often characterized by a persistent increase in the …

Research published in Science Signaling identifies previously uncharacterized regulators of
the inflammatory response, characterizes feedback mechanisms that modulate …

Cytokines are key instigators and regulators of immune responses and therefore hold great
potential as targets for new therapeutic strategies. However, the selection of which cytokines …

Inflammation is one of the vital mechanisms through which the immune system responds to
harmful stimuli. During inflammation, proinflammatory and anti-inflammatory cytokines …

We are now standing at the cusp of systems-based understanding of the processes that
underlie, drive, and control the acute inflammatory response. Based on decades of …

Critical illness, a constellation of interrelated inflammatory and physiological derangements
occurring subsequent to severe infection or injury, affects a large number of individuals in …

A central goal of industrialized nations is to provide personalized, pre-emptive and
predictive medicine, while maintaining healthcare costs at a minimum. To do so, we must …