[PDF][PDF] Neuro-COVID long-haulers exhibit broad dysfunction in T cell memory generation and responses to vaccination

L Visvabharathy, B Hanson, Z Orban, PH Lim… - MedRxiv, 2021 - medrxiv.org
The high prevalence of post-acute sequelae of SARS-CoV-2 infection (PASC) is a significant
health concern. In particular, virus-specific immunity in patients who suffer from chronic …

Neuro-PASC is characterized by enhanced CD4+ and diminished CD8+ T cell responses to SARS-CoV-2 Nucleocapsid protein

L Visvabharathy, BA Hanson, ZS Orban… - Frontiers in …, 2023 - frontiersin.org
Introduction Many people with long COVID symptoms suffer from debilitating neurologic post-
acute sequelae of SARS-CoV-2 infection (Neuro-PASC). Although symptoms of Neuro …

[HTML][HTML] Mild respiratory SARS-CoV-2 infection can cause multi-lineage cellular dysregulation and myelin loss in the brain

A Fernández-Castañeda, P Lu, AC Geraghty, E Song… - BioRxiv, 2022 - ncbi.nlm.nih.gov
Abstract Survivors of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)
infection frequently experience lingering neurological symptoms, including impairment in …

Severe Neuro-COVID is associated with peripheral immune signatures, autoimmunity and neurodegeneration: a prospective cross-sectional study

MM Etter, TA Martins, L Kulsvehagen… - Nature …, 2022 - nature.com
Growing evidence links COVID-19 with acute and long-term neurological dysfunction.
However, the pathophysiological mechanisms resulting in central nervous system …

Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms

E Song, CM Bartley, RD Chow, TT Ngo, R Jiang… - Cell Reports …, 2021 - cell.com
Individuals with coronavirus disease 2019 (COVID-19) frequently develop neurological
symptoms, but the biological underpinnings of these phenomena are unknown. Through …

[HTML][HTML] Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19

T Sekine, A Perez-Potti, O Rivera-Ballesteros, K Strålin… - Cell, 2020 - cell.com
Summary SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune
protection against COVID-19. Here, we systematically mapped the functional and …

The pandemic brain: Neuroinflammation in non-infected individuals during the COVID-19 pandemic

L Brusaferri, Z Alshelh, D Martins, M Kim… - Brain, behavior, and …, 2022 - Elsevier
While COVID-19 research has seen an explosion in the literature, the impact of pandemic-
related societal and lifestyle disruptions on brain health among the uninfected remains …

Neurologic sequelae of COVID-19 are determined by immunologic imprinting from previous coronaviruses

M Spatola, N Nziza, W Jung, Y Deng, D Yuan, A Dinoto… - Brain, 2023 - academic.oup.com
Abstract Coronavirus disease 2019 (COVID-19), which is caused by the severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a global public health …

[HTML][HTML] Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions

M Schwabenland, H Salié, J Tanevski, S Killmer… - Immunity, 2021 - cell.com
COVID-19 can cause severe neurological symptoms, but the underlying pathophysiological
mechanisms are unclear. Here, we interrogated the brain stems and olfactory bulbs in …

[HTML][HTML] What SARS-CoV-2 does to our brains

T Aschman, R Mothes, FL Heppner, H Radbruch - Immunity, 2022 - cell.com
Neurological symptoms in SARS-CoV-2-infected patients have been reported, but their
cause remains unclear. In theory, the neurological symptoms observed after SARS-CoV-2 …